Albumin Binding Function: The Potential Earliest Indicator for Liver Function Damage
Joint Authors
Ge, Penglei
Yang, Huayu
Lu, Jingfen
Liao, Wenjun
Du, Shunda
Xu, Yingli
Xu, Haifeng
Lu, Xin
Sang, Xinting
Zhong, Shouxian
Huang, Jiefu
Mao, Yilei
Zhao, Haitao
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Currently there is no indicator that can evaluate actual liver lesion for early stages of viral hepatitis, nonalcoholic fatty liver disease (NAFLD), and cirrhosis.
Aim of this study was to investigate if albumin binding function could better reflect liver function in these liver diseases.
Methods.
An observational study was performed on 193 patients with early NAFLD, viral hepatitis, and cirrhosis.
Cirrhosis patients were separated according to Child-Pugh score into A, B, and C subgroup.
Albumin metal ion binding capacity (Ischemia-modified albumin transformed, IMAT) and fatty acid binding capacity (total binding sites, TBS) were detected.
Results.
Both IMAT and TBS were significantly decreased in patients with NAFLD and early hepatitis.
In hepatitis group, they declined prior to changes of liver enzymes.
IMAT was significantly higher in cirrhosis Child-Pugh class A group than hepatitis patients and decreased in Child-Pugh class B and class C patients.
Both IMAT/albumin and TBS/albumin decreased significantly in hepatitis and NAFLD group patients.
Conclusions.
This is the first study to discover changes of albumin metal ion and fatty acid binding capacities prior to conventional biomarkers for liver damage in early stage of liver diseases.
They may become potential earliest sensitive indicators for liver function evaluation.
American Psychological Association (APA)
Ge, Penglei& Yang, Huayu& Lu, Jingfen& Liao, Wenjun& Du, Shunda& Xu, Yingli…[et al.]. 2016. Albumin Binding Function: The Potential Earliest Indicator for Liver Function Damage. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104704
Modern Language Association (MLA)
Ge, Penglei…[et al.]. Albumin Binding Function: The Potential Earliest Indicator for Liver Function Damage. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1104704
American Medical Association (AMA)
Ge, Penglei& Yang, Huayu& Lu, Jingfen& Liao, Wenjun& Du, Shunda& Xu, Yingli…[et al.]. Albumin Binding Function: The Potential Earliest Indicator for Liver Function Damage. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104704
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104704