Correlation between Histological Activity and Endoscopic, Clinical, and Serologic Activities in Patients with Ulcerative Colitis
Joint Authors
Lee, Kang-Moon
Paik, Chang Nyol
Kim, Dae Bum
Lee, Ji Min
Chung, Yoon Yung
Sung, Hea Jung
Jung, Ji-Han
Choi, Hyun Joo
Chung, Woo Chul
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objectives.
Recent studies suggest that histological healing is a treatment goal in ulcerative colitis (UC).
We aimed to evaluate the correlation between histological activity and clinical, endoscopic, and serologic activities in patients with UC.
Methods.
We retrospectively reviewed medical records from patients with UC who underwent colonoscopy or sigmoidoscopy with biopsies.
The Mayo endoscopic subscore was used to assess endoscopic activity.
Biopsy specimens were reviewed by two blinded pathologists and scored using the Geboes scoring system.
Results.
We analyzed 154 biopsy specimens from 82 patients with UC.
Histological scores exhibited strong correlation with endoscopic subscores (Spearman’s rank correlation coefficient r = 0.774 , p < 0.001 ) and moderate correlation with C-reactive protein levels ( r = 0.422 , p < 0.001 ) and partial Mayo scores ( r = 0.403 , p < 0.001 ).
Active histological inflammation (Geboes score ≥ 3.1) was observed in 6% (2 of 33) of the endoscopically normal mucosa samples, 66% (19 of 29) of mild disease samples, and 98% (90 of 92) of moderate-to-severe disease samples.
Conclusions.
Histological activity was closely correlated with the endoscopic, clinical, and serologic UC activities.
However, several patients with mild or normal endoscopic findings exhibited histological evidence of inflammation.
Therefore, histological assessment may be helpful in evaluating treatment outcomes and determining follow-up strategies.
American Psychological Association (APA)
Kim, Dae Bum& Lee, Kang-Moon& Lee, Ji Min& Chung, Yoon Yung& Sung, Hea Jung& Paik, Chang Nyol…[et al.]. 2015. Correlation between Histological Activity and Endoscopic, Clinical, and Serologic Activities in Patients with Ulcerative Colitis. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104719
Modern Language Association (MLA)
Kim, Dae Bum…[et al.]. Correlation between Histological Activity and Endoscopic, Clinical, and Serologic Activities in Patients with Ulcerative Colitis. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1104719
American Medical Association (AMA)
Kim, Dae Bum& Lee, Kang-Moon& Lee, Ji Min& Chung, Yoon Yung& Sung, Hea Jung& Paik, Chang Nyol…[et al.]. Correlation between Histological Activity and Endoscopic, Clinical, and Serologic Activities in Patients with Ulcerative Colitis. Gastroenterology Research and Practice. 2015. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104719
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104719