Bowel Perforation in Premature Infants with Necrotizing Enterocolitis: Risk Factors and Outcomes
Joint Authors
Zhu, Xueping
Yu, Lingling
Tian, Jianmei
Zhao, Xingli
Cheng, Ping
Chen, Xiaoqian
Yu, Yun
Ding, Xiaochun
Xiao, Zhihui
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We aim to determine risk factors and clinical outcomes for bowel perforation in premature infants with NEC.
We analyzed clinical data of 57 cases of premature infants with NEC at our NICU between January 2010 and December 2012.
Based on the presence of bowel perforation, we divided these infants into two groups: perforated NEC group (n=10) and nonperforated NEC group (n=47).
We compared general information, clinical characteristics, and laboratory findings between groups.
The perforated NEC group, compared to the nonperforated NEC group, had significantly lesser gestational age, lower birth weight, higher prevalence of apnea, mechanical ventilation, sepsis and shock, lower blood pH, higher levels of blood glucose, abnormal WBC count and thrombocytopenia, and elevated CRP (all P<0.05).
Moreover, the perforated NEC group had significantly longer durations of fasting and TPN usage, higher incidences of EUGR and cholestasis, longer duration of antibiotics, higher frequency of advanced antibiotics use, and poorer prognosis than the nonperforated NEC group (all P<0.05).
Bowel perforation in premature infants with NEC was associated with multiple risk factors.
Early identification of some of these risk factors in premature infants with NEC may help implement early intervention to reduce the incidence of bowel perforation and thereby improve the prognosis.
American Psychological Association (APA)
Yu, Lingling& Tian, Jianmei& Zhao, Xingli& Cheng, Ping& Chen, Xiaoqian& Yu, Yun…[et al.]. 2016. Bowel Perforation in Premature Infants with Necrotizing Enterocolitis: Risk Factors and Outcomes. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104727
Modern Language Association (MLA)
Yu, Lingling…[et al.]. Bowel Perforation in Premature Infants with Necrotizing Enterocolitis: Risk Factors and Outcomes. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1104727
American Medical Association (AMA)
Yu, Lingling& Tian, Jianmei& Zhao, Xingli& Cheng, Ping& Chen, Xiaoqian& Yu, Yun…[et al.]. Bowel Perforation in Premature Infants with Necrotizing Enterocolitis: Risk Factors and Outcomes. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104727
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104727