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Cancer-Associated Immune Resistance and Evasion of Immune Surveillance in Colorectal Cancer
Joint Authors
Laudanna, Carmelo
Giordano, Guido
Pancione, Massimo
Febbraro, Antonio
Parcesepe, Pietro
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Data from molecular profiles of tumors and tumor associated cells provide a model in which cancer cells can acquire the capability of avoiding immune surveillance by expressing an immune-like phenotype.
Recent works reveal that expression of immune antigens (PDL1, CD47, CD73, CD14, CD68, MAC387, CD163, DAP12, and CD15) by tumor cells “immune resistance,” combined with prometastatic function of nonmalignant infiltrating cells, may represent a strategy to overcome the rate-limiting steps of metastatic cascade through (a) enhanced interactions with protumorigenic myeloid cells and escape from T-dependent immune response mediated by CD8+ and natural killer (NK) cells; (b) production of immune mediators that establish a local and systemic tumor-supportive environment (premetastatic niche); (c) ability to survive either in the peripheral blood as circulating tumor cells (CTCs) or at the metastatic site forming a cooperative prometastatic loop with foreign “myeloid” cells, macrophages, and neutrophils, respectively.
The development of cancer-specific “immune resistance” can be orchestrated either by cooperation with tumor microenvironment or by successive rounds of genetic/epigenetic changes.
Recognition of the applicability of this model may provide effective therapeutic avenues for complete elimination of immune-resistant metastatic cells and for enhanced antitumor immunity as part of a combinatorial strategy.
American Psychological Association (APA)
Parcesepe, Pietro& Giordano, Guido& Laudanna, Carmelo& Febbraro, Antonio& Pancione, Massimo. 2016. Cancer-Associated Immune Resistance and Evasion of Immune Surveillance in Colorectal Cancer. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104735
Modern Language Association (MLA)
Parcesepe, Pietro…[et al.]. Cancer-Associated Immune Resistance and Evasion of Immune Surveillance in Colorectal Cancer. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1104735
American Medical Association (AMA)
Parcesepe, Pietro& Giordano, Guido& Laudanna, Carmelo& Febbraro, Antonio& Pancione, Massimo. Cancer-Associated Immune Resistance and Evasion of Immune Surveillance in Colorectal Cancer. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104735
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104735