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Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy for Management of Peritoneal Sarcomatosis: A Preliminary Single-Center Experience from Saudi Arabia
Joint Authors
Elhassan, Tusneem
Abuzaid, Mohammed
Albadawi, Naryman
Alkhatib, Lynn
AlOmar, Osama
Alsuhaibani, Abdullah
Abu-Zaid, Ahmed
Azzam, Ayman
al-Badawi, Ismail A.
Amin, Tarek
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aim.
To report our preliminary single-center experience with cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) for management of peritoneal sarcomatosis (PS).
Methods.
Eleven patients were retrospectively analyzed for perioperative details.
Results.
Cytoreduction completeness (CC-0/1) was achieved in all patients with median peritoneal cancer index (PCI) of 14 ± 8.9 (range: 3–29).
Combination cisplatin + doxorubicin HIPEC chemotherapy was used in 6 patients.
Five patients received intraoperative radiation therapy (IORT).
The median operative time, estimated blood loss, and hospital stay were 8 ± 1.4 hours (range: 6–10), 1000 ± 250 mL (range: 700–3850), and 11 ± 2.4 days (range: 7–15), respectively.
Major postoperative Clavien-Dindo grade III/IV complications occurred in 1 patient and none developed HIPEC chemotherapy-related toxicities.
The median overall survival (OS) and disease-free survival (DFS) after CRS + HIPEC were 28.3 ± 3.2 and 18.0 ± 4.0 months, respectively.
The median follow-up time was 12 months (range: 6–33).
Univariate analysis of several prognostic factors (age, gender, PS presentation/pathology, CC, PCI, HIPEC chemotherapy, and IORT) did not demonstrate statistically significant differences of OS and DFS.
Conclusion.
CRS + HIPEC appear to be feasible, safe, and offer survival oncological benefits.
However, definitive conclusions cannot be deduced.
American Psychological Association (APA)
Abu-Zaid, Ahmed& Azzam, Ayman& Abuzaid, Mohammed& Elhassan, Tusneem& Albadawi, Naryman& Alkhatib, Lynn…[et al.]. 2016. Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy for Management of Peritoneal Sarcomatosis: A Preliminary Single-Center Experience from Saudi Arabia. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104749
Modern Language Association (MLA)
Abu-Zaid, Ahmed…[et al.]. Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy for Management of Peritoneal Sarcomatosis: A Preliminary Single-Center Experience from Saudi Arabia. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1104749
American Medical Association (AMA)
Abu-Zaid, Ahmed& Azzam, Ayman& Abuzaid, Mohammed& Elhassan, Tusneem& Albadawi, Naryman& Alkhatib, Lynn…[et al.]. Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy for Management of Peritoneal Sarcomatosis: A Preliminary Single-Center Experience from Saudi Arabia. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104749
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104749