Xyloglucan for the Treatment of Acute Gastroenteritis in Children: Results of a Randomized, Controlled, Clinical Trial
Joint Authors
Pleșea Condratovici, Cătălin
Bacarea, Vladimir
Piqué, Núria
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Xyloglucan, a film-forming agent, improves intestinal mucosa resistance to pathologic damage.
The efficacy, safety, and time of onset of the antidiarrheal effect of xyloglucan were assessed in children with acute gastroenteritis receiving oral rehydration solution (ORS).
Methods.
This randomized, controlled, open-label, parallel-group, multicenter, clinical trial included children (3 months–12 years) with acute gastroenteritis of infectious origin.
Children were randomized to xyloglucan and ORS, or ORS only, for 5 days.
Diarrheal symptoms, including stool number/characteristics, and safety were assessed at baseline and after 2 and 5 days and by fulfillment of a parent diary card.
Results.
Thirty-six patients (58.33% girls) were included (n=18/group).
Patients receiving xyloglucan and ORS had better symptom evolution than ORS-only recipients, with a faster onset of action.
At 6 hours, xyloglucan produced a significantly greater decrease in the number of type 7 stools (0.11 versus 0.44; P=0.027).
At days 3 and 5, xyloglucan also produced a significantly greater reduction in types 6 and 7 stools compared with ORS alone.
Xyloglucan plus ORS was safe and well tolerated.
Conclusions.
Xyloglucan is an efficacious and safe option for the treatment of acute gastroenteritis in children, with a rapid onset of action in reducing diarrheal symptoms.
This study is registered with ISRCTN number 65893282.
American Psychological Association (APA)
Pleșea Condratovici, Cătălin& Bacarea, Vladimir& Piqué, Núria. 2016. Xyloglucan for the Treatment of Acute Gastroenteritis in Children: Results of a Randomized, Controlled, Clinical Trial. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104759
Modern Language Association (MLA)
Pleșea Condratovici, Cătălin…[et al.]. Xyloglucan for the Treatment of Acute Gastroenteritis in Children: Results of a Randomized, Controlled, Clinical Trial. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1104759
American Medical Association (AMA)
Pleșea Condratovici, Cătălin& Bacarea, Vladimir& Piqué, Núria. Xyloglucan for the Treatment of Acute Gastroenteritis in Children: Results of a Randomized, Controlled, Clinical Trial. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104759
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104759