Comparison of Inflammatory Response to Transgastric and Transcolonic NOTES
Joint Authors
Lánská, Věra
Hucl, Tomas
Benes, Marek
Kocik, Matej
Splichalova, Alla
Maluskova, Jana
Krak, Martin
Heczkova, Marie
Kieslichova, Eva
Oliverius, Martin
Spicak, Julius
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aims.
The aim of our study was to determine the physiologic impact of NOTES and to compare the transgastric and transcolonic approaches.
Methods.
Thirty pigs were randomized to transgastric, transcolonic, or laparoscopic peritoneoscopy.
Blood was drawn and analyzed for C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin- (IL-) 1β, IL-6, WBCs, and platelets.
Results.
Endoscopic closure with an OTSC was successful in all 20 animals.
The postoperative course was uneventful in all animals.
CRP values rose on day 1 in all animals and slowly declined to baseline levels on day 14 with no differences between the groups ( P > 0.05 , NS).
The levels of TNF-α were significantly increased in the transcolonic group ( P < 0.01 ); however this difference was already present prior to the procedure and remained unchanged.
No differences were observed in IL1-β and IL-6 values.
There was a temporary rise of WBC on day 1 and of platelets on day 7 in all groups ( P > 0.05 , NS).
Conclusions.
Transgastric, transcolonic, and laparoscopic peritoneoscopy resulted in similar changes in systemic inflammatory markers.
Our findings do not support the assumption that NOTES is less invasive than laparoscopy.
American Psychological Association (APA)
Hucl, Tomas& Benes, Marek& Kocik, Matej& Splichalova, Alla& Maluskova, Jana& Krak, Martin…[et al.]. 2016. Comparison of Inflammatory Response to Transgastric and Transcolonic NOTES. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104773
Modern Language Association (MLA)
Hucl, Tomas…[et al.]. Comparison of Inflammatory Response to Transgastric and Transcolonic NOTES. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1104773
American Medical Association (AMA)
Hucl, Tomas& Benes, Marek& Kocik, Matej& Splichalova, Alla& Maluskova, Jana& Krak, Martin…[et al.]. Comparison of Inflammatory Response to Transgastric and Transcolonic NOTES. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104773
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104773