Crosstalk between Inflammation and ROCKMLCK Signaling Pathways in Gastrointestinal Disorders with Intestinal Hyperpermeability
Joint Authors
Kim, John J.
Dai, Ning
Du, Lijun
Shen, Jinhua
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The barrier function of the intestine is essential for maintaining the normal homeostasis of the gut and mucosal immune system.
Abnormalities in intestinal barrier function expressed by increased intestinal permeability have long been observed in various gastrointestinal disorders such as Crohn’s disease (CD), ulcerative colitis (UC), celiac disease, and irritable bowel syndrome (IBS).
Imbalance of metabolizing junction proteins and mucosal inflammation contributes to intestinal hyperpermeability.
Emerging studies exploring in vitro and in vivo model system demonstrate that Rho-associated coiled-coil containing protein kinase- (ROCK-) and myosin light chain kinase- (MLCK-) mediated pathways are involved in the regulation of intestinal permeability.
With this perspective, we aim to summarize the current state of knowledge regarding the role of inflammation and ROCK-/MLCK-mediated pathways leading to intestinal hyperpermeability in gastrointestinal disorders.
In the near future, it may be possible to specifically target these specific pathways to develop novel therapies for gastrointestinal disorders associated with increased gut permeability.
American Psychological Association (APA)
Du, Lijun& Kim, John J.& Shen, Jinhua& Dai, Ning. 2016. Crosstalk between Inflammation and ROCKMLCK Signaling Pathways in Gastrointestinal Disorders with Intestinal Hyperpermeability. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104775
Modern Language Association (MLA)
Du, Lijun…[et al.]. Crosstalk between Inflammation and ROCKMLCK Signaling Pathways in Gastrointestinal Disorders with Intestinal Hyperpermeability. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1104775
American Medical Association (AMA)
Du, Lijun& Kim, John J.& Shen, Jinhua& Dai, Ning. Crosstalk between Inflammation and ROCKMLCK Signaling Pathways in Gastrointestinal Disorders with Intestinal Hyperpermeability. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104775
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104775