Effects of Lactobacillus gasseri OLL2716 on Helicobacter pylori-Associated Dyspepsia: A Multicenter Randomized Double-Blind Controlled Trial
Joint Authors
Ozawa, Hideki
Takagi, Atsushi
Inoue, Kazuhiko
Yanagi, Hidetaka
Nakajima, Shigemi
Kawai, Takashi
Ohtsu, Toshihiro
Koga, Yasuhiro
Uemura, Naomi
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Some Lactobacillus spp.
suppress Helicobacter pylori in the stomach and have potential therapeutic applications for the treatment of gastrointestinal conditions.
In this study, the effects of Lactobacillus strains on functional dyspepsia associated with H.
pylori infection were examined.
Volunteers were screened using the 13C-urea breath test (UBT) and H.
pylori stool test, and 131 participants who met the selection criteria (mean age: 48.9 years) were randomly given L.
gasseri OLL2716-containing yogurt or placebo yogurt once daily for 12 weeks.
Gastrointestinal symptoms (epigastric pain, bloating, postprandial fullness, nausea, and heartburn) and the levels of serum pepsinogen (PG), 13C-UBT, and H.
pylori stool antigen were assessed.
No significant differences were observed between the groups in UBT results, H.
pylori stool antigens, or the serum PGI/II ratio.
In the L.
gasseri group, postprandial fullness was significantly lower at the end of the trial compared to the initial level ( p < 0.05 ) and significantly fewer patients had a VAS score of >10 for bloating compared to the placebo group ( p < 0.05 ).
Dietary supplementation with L.
gasseri OLL2716-containing yogurt may effectively suppress dyspeptic symptoms in H.
pylori-infected patients.
This study was registered at the University Hospital Medical Network Clinical Trial Registry (UMIN000016746).
American Psychological Association (APA)
Takagi, Atsushi& Yanagi, Hidetaka& Ozawa, Hideki& Uemura, Naomi& Nakajima, Shigemi& Inoue, Kazuhiko…[et al.]. 2016. Effects of Lactobacillus gasseri OLL2716 on Helicobacter pylori-Associated Dyspepsia: A Multicenter Randomized Double-Blind Controlled Trial. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104780
Modern Language Association (MLA)
Takagi, Atsushi…[et al.]. Effects of Lactobacillus gasseri OLL2716 on Helicobacter pylori-Associated Dyspepsia: A Multicenter Randomized Double-Blind Controlled Trial. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1104780
American Medical Association (AMA)
Takagi, Atsushi& Yanagi, Hidetaka& Ozawa, Hideki& Uemura, Naomi& Nakajima, Shigemi& Inoue, Kazuhiko…[et al.]. Effects of Lactobacillus gasseri OLL2716 on Helicobacter pylori-Associated Dyspepsia: A Multicenter Randomized Double-Blind Controlled Trial. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104780
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104780