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Associations between White Blood Cell Count and the Development of Incidental Nonalcoholic Fatty Liver Disease
Joint Authors
Chung, Goh Eun
Yim, Jeong Yoon
Kim, Donghee
Yang, Sun Young
Kwak, Min-Sun
Kim, Joo Sung
Yang, Jong In
Chung, Su Jin
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aims.
Chronic low-grade inflammation is thought to be associated with the pathogenesis of nonalcoholic fatty liver disease (NAFLD).
This study aimed to determine the association between serum white blood cell (WBC) counts and the development of incidental NAFLD.
Methods.
In this retrospective longitudinal cohort study, we recruited participants who underwent abdominal ultrasonography and blood samplings during medical checkups in both 2005 and 2010.
A total of 2,216 subjects were included in our analyses.
Results.
The prevalence of NAFLD in 2010 increased steadily in conjunction with increasing WBC counts in 2005 after adjustment for body mass index (BMI) [odds ratio (OR) 2.44, 95% confidence interval (CI) = 1.49–4.00 for women and OR 2.42, 95% CI = 1.61–3.63 for men, lowest quartile versus highest quartile].
Multivariate regression analysis after adjusting for age, BMI, hypertension, smoking, triglycerides, HDL cholesterol, and glucose levels revealed that NAFLD was significantly associated with the highest WBC quartile compared to the lowest quartile [OR 1.85, 95% CI, 1.10−3.10 for women and OR 1.68, 95% CI, 1.08−2.61 for men].
Conclusions.
We demonstrated that the risk of developing NAFLD was significantly associated with WBC counts independently of metabolic factors.
This finding provides novel evidence indicating that serum WBC counts may be potential surrogate markers of NAFLD.
American Psychological Association (APA)
Chung, Goh Eun& Yim, Jeong Yoon& Kim, Donghee& Kwak, Min-Sun& Yang, Jong In& Chung, Su Jin…[et al.]. 2016. Associations between White Blood Cell Count and the Development of Incidental Nonalcoholic Fatty Liver Disease. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104784
Modern Language Association (MLA)
Chung, Goh Eun…[et al.]. Associations between White Blood Cell Count and the Development of Incidental Nonalcoholic Fatty Liver Disease. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1104784
American Medical Association (AMA)
Chung, Goh Eun& Yim, Jeong Yoon& Kim, Donghee& Kwak, Min-Sun& Yang, Jong In& Chung, Su Jin…[et al.]. Associations between White Blood Cell Count and the Development of Incidental Nonalcoholic Fatty Liver Disease. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104784
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104784