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Synergistic Effects of Simvastatin and Irinotecan against Colon Cancer Cells with or without Irinotecan Resistance
Joint Authors
Jang, Hyun Joo
Hong, Eun Mi
Jang, Juah
Choi, Jung Eun
Park, Se Woo
Byun, Hyun Woo
Koh, Dong Hee
Choi, Min Ho
Kae, Sea Hyub
Lee, Jin
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aims.
We here investigated whether the combination of simvastatin and irinotecan could induce the synergistic effect on colon cancer cells with or without resistance to irinotecan.
Methods.
We investigated cell proliferation assay and assessed cell death detection ELISA and caspase-3 activity assay of various concentrations of simvastatin and irinotecan to evaluate the efficacy of drug combination on colon cancer cells with or without irinotecan resistance.
Results.
The IC50 values of simvastatin alone and irinotecan alone were 115.4±0.14 μM (r=0.98) and 62.5±0.18 μM (r=0.98) in HT-29 cells without resistance to irinotecan.
The IC50 values of these two drugs were 221.9±0.22 μM (r=0.98) and 195.9±0.16 μM (r=0.99), respectively, in HT-29 cell with resistance to irinotecan.
The results of combinations of the various concentrations of two drugs showed that combined treatment with irinotecan and simvastatin more efficiently suppressed cell proliferation of HT-29 cells even with resistance to irinotecan as well as without resistance.
Furthermore, the combination of simvastatin and irinotecan at 2:1 molar ratio showed the best synergistic interaction.
Conclusion.
Simvastatin could act synergistically with irinotecan to overcome irinotecan resistance of colon cancer.
American Psychological Association (APA)
Jang, Hyun Joo& Hong, Eun Mi& Jang, Juah& Choi, Jung Eun& Park, Se Woo& Byun, Hyun Woo…[et al.]. 2016. Synergistic Effects of Simvastatin and Irinotecan against Colon Cancer Cells with or without Irinotecan Resistance. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104792
Modern Language Association (MLA)
Jang, Hyun Joo…[et al.]. Synergistic Effects of Simvastatin and Irinotecan against Colon Cancer Cells with or without Irinotecan Resistance. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1104792
American Medical Association (AMA)
Jang, Hyun Joo& Hong, Eun Mi& Jang, Juah& Choi, Jung Eun& Park, Se Woo& Byun, Hyun Woo…[et al.]. Synergistic Effects of Simvastatin and Irinotecan against Colon Cancer Cells with or without Irinotecan Resistance. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104792
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104792