Screening Driving Transcription Factors in the Processing of Gastric Cancer
Joint Authors
Xu, Guangzhong
Li, Kai
Zhang, Nengwei
Zhu, Bin
Feng, Guosheng
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Construction of the transcriptional regulatory network can provide additional clues on the regulatory mechanisms and therapeutic applications in gastric cancer.
Methods.
Gene expression profiles of gastric cancer were downloaded from GEO database for integrated analysis.
All of DEGs were analyzed by GO enrichment and KEGG pathway enrichment.
Transcription factors were further identified and then a global transcriptional regulatory network was constructed.
Results.
By integrated analysis of the six eligible datasets (340 cases and 43 controls), a bunch of 2327 DEGs were identified, including 2100 upregulated and 227 downregulated DEGs.
Functional enrichment analysis of DEGs showed that digestion was a significantly enriched GO term for biological process.
Moreover, there were two important enriched KEGG pathways: cell cycle and homologous recombination.
Furthermore, a total of 70 differentially expressed TFs were identified and the transcriptional regulatory network was constructed, which consisted of 566 TF-target interactions.
The top ten TFs regulating most downstream target genes were BRCA1, ARID3A, EHF, SOX10, ZNF263, FOXL1, FEV, GATA3, FOXC1, and FOXD1.
Most of them were involved in the carcinogenesis of gastric cancer.
Conclusion.
The transcriptional regulatory network can help researchers to further clarify the underlying regulatory mechanisms of gastric cancer tumorigenesis.
American Psychological Association (APA)
Xu, Guangzhong& Li, Kai& Zhang, Nengwei& Zhu, Bin& Feng, Guosheng. 2016. Screening Driving Transcription Factors in the Processing of Gastric Cancer. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104809
Modern Language Association (MLA)
Xu, Guangzhong…[et al.]. Screening Driving Transcription Factors in the Processing of Gastric Cancer. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1104809
American Medical Association (AMA)
Xu, Guangzhong& Li, Kai& Zhang, Nengwei& Zhu, Bin& Feng, Guosheng. Screening Driving Transcription Factors in the Processing of Gastric Cancer. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104809
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104809