Cerebral Hemodynamics and Cognitive Function in Cirrhotic Patients with Hepatic Encephalopathy
Joint Authors
Lu, Jie
Li, Jingjing
Li, Sainan
Liu, Tong
Zhou, Yuqing
Zhang, Rong
Dong, Qian
Zhou, Shunfeng
Li, Linqiang
Cheng, Keran
Kong, Rui
Yu, Qiang
Xu, Shizan
Feng, Jiao
Wu, Liwei
Lu, Xiya
Xia, Yujing
Zhou, Ying-Qun
Chen, Kan
Guo, Chuan-Yong
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-21
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Aims.
To investigate cerebral hemodynamics in cirrhotic patients with HE and to observe effects of treatment in cerebral hemodynamics and correlations among ammonia, cerebral hemodynamics, and cognitive function.
Methods.
There were four groups: healthy controls (group 1), cirrhosis without HE (group 2), cirrhosis with MHE (group 3), and cirrhosis with OHE (group 4).
Ammonia and cerebral hemodynamics (by TCD) were assessed.
Patients in group 3 were subsequently randomized to two subgroups: the control (group A) and the treated (group B, treated with lactulose for two months), and they were retested for ammonia and TCD after treatment.
Results.
Ammonia, Vm, Vd, PI, and RI were statistically different before treatment, and ammonia, PI, and RI levels paralleled the severity of HE (P<0.05).
In group B, Vd increased and ammonia, PI, and RI declined following treatment (P<0.05), while there were no differences in group A (P>0.05).
Correlations were found between ammonia and Vd, PI, RI, NCT-A, and DST and also found between Vd, PI, RI, and NCT-A and DST (P<0.05).
Conclusions.
This study revealed that cerebral hemodynamics were related to the severity of HE and cerebral autoregulation was impaired.
There were tight correlations among ammonia, cerebral hemodynamics, and cognitive function, and, following treatment, cerebral hemodynamics improved.
American Psychological Association (APA)
Zhou, Yuqing& Dong, Qian& Zhang, Rong& Zhou, Shunfeng& Li, Linqiang& Cheng, Keran…[et al.]. 2016. Cerebral Hemodynamics and Cognitive Function in Cirrhotic Patients with Hepatic Encephalopathy. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1104812
Modern Language Association (MLA)
Zhou, Yuqing…[et al.]. Cerebral Hemodynamics and Cognitive Function in Cirrhotic Patients with Hepatic Encephalopathy. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1104812
American Medical Association (AMA)
Zhou, Yuqing& Dong, Qian& Zhang, Rong& Zhou, Shunfeng& Li, Linqiang& Cheng, Keran…[et al.]. Cerebral Hemodynamics and Cognitive Function in Cirrhotic Patients with Hepatic Encephalopathy. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1104812
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104812