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Lower Viral Response to Pegylated Interferon Alpha 2a Treatment of Chronic Hepatitis B in Roma People in Eastern Slovakia
Joint Authors
Drazilova, Sylvia
Janicko, Martin
Kristian, Pavol
Schreter, Ivan
Kucinsky, Branislav
Kozlej, Marek
Hockickova, Ivana
Jarcuska, Peter
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aim.
To evaluate the compliance and virological response to pegylated interferon alpha 2a treatment of chronic hepatitis B in Roma population compared to majority Caucasian population in Slovakia.
Methods.
Retrospective evaluation of a cohort of all Roma patients treated with pegylated interferon alpha 2a from 2007 to 2013 in 3 centers for treatment of chronic viral hepatitis B.
The Study included 43 Roma patients with chronic viral hepatitis B and randomly selected control group.
Treatment duration was 48 weeks.
Viral response was evaluated after 24 weeks, at the end of treatment, and 24 weeks after the end of treatment.
Results.
Complete treatment course was finished by 79.1% of Roma patients compared to all patients from the control group p=0.0009.
There was a tendency toward lower viral response rate in Roma at all time points; however significant difference was only at end of treatment viral response (51.2% Roma versus 81.4% majority, p=0.003).
We also did not find significant difference at the rate of HBsAg loss.
Conclusion.
Roma patients with chronic hepatitis B have significantly worse compliance to treatment with pegylated interferon and they have significantly lower rate of end of treatment viral response.
American Psychological Association (APA)
Drazilova, Sylvia& Janicko, Martin& Kristian, Pavol& Schreter, Ivan& Kucinsky, Branislav& Kozlej, Marek…[et al.]. 2015. Lower Viral Response to Pegylated Interferon Alpha 2a Treatment of Chronic Hepatitis B in Roma People in Eastern Slovakia. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104817
Modern Language Association (MLA)
Drazilova, Sylvia…[et al.]. Lower Viral Response to Pegylated Interferon Alpha 2a Treatment of Chronic Hepatitis B in Roma People in Eastern Slovakia. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1104817
American Medical Association (AMA)
Drazilova, Sylvia& Janicko, Martin& Kristian, Pavol& Schreter, Ivan& Kucinsky, Branislav& Kozlej, Marek…[et al.]. Lower Viral Response to Pegylated Interferon Alpha 2a Treatment of Chronic Hepatitis B in Roma People in Eastern Slovakia. Gastroenterology Research and Practice. 2015. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104817
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104817