A Comparison of a Fully Covered and an Uncovered Segmented Biodegradable Esophageal Stent in a Porcine Model: Preclinical Evaluation of Degradation, Complications, and Tissue Reactions
Joint Authors
Shi, Ruihua
Feng, Yadong
Jiao, Chunhua
Cao, Yang
Zhao, Ye
Chen, Yanfang
Fang, Lin
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aims.
This study was to compare the degradation, complications, and tissue reactions of two segmented biodegradable esophageal stents in a porcine model.
Methods.
Uncovered biodegradable segmented stents and fully covered biodegradable segmented stents (FCBDS) were transplanted into the porcine esophagus lumen.
Data on biodegradation, complications, and tissue reactions were collected and compared.
Results.
All animals kept good general conditions.
No severe complications and stents migration occurred.
Stents degradation commenced at week 3.
Compared with uncovered stents, stents structure breakage and complete stents absorption in FCBDS were postponed for 1-2 weeks.
Hyperplasia was prominent at early stage and ameliorated at late stage after stents insertion.
Tissue reactions in FCBDS were milder than those in uncovered stents in the early stage.
A longer degradation period was present in FCBDS than in uncovered stents, while FCBDS induced tissue reaction at late stage was mild.
Conclusions.
Biodegradable esophageal stents with a segmented trunk may be further evaluated in refractory benign esophagus strictures.
This FCBDS may be advantageous compared with uncovered stents for a longer degradation period.
American Psychological Association (APA)
Feng, Yadong& Jiao, Chunhua& Cao, Yang& Zhao, Ye& Chen, Yanfang& Fang, Lin…[et al.]. 2016. A Comparison of a Fully Covered and an Uncovered Segmented Biodegradable Esophageal Stent in a Porcine Model: Preclinical Evaluation of Degradation, Complications, and Tissue Reactions. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104818
Modern Language Association (MLA)
Feng, Yadong…[et al.]. A Comparison of a Fully Covered and an Uncovered Segmented Biodegradable Esophageal Stent in a Porcine Model: Preclinical Evaluation of Degradation, Complications, and Tissue Reactions. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1104818
American Medical Association (AMA)
Feng, Yadong& Jiao, Chunhua& Cao, Yang& Zhao, Ye& Chen, Yanfang& Fang, Lin…[et al.]. A Comparison of a Fully Covered and an Uncovered Segmented Biodegradable Esophageal Stent in a Porcine Model: Preclinical Evaluation of Degradation, Complications, and Tissue Reactions. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104818
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104818