Transarterial Embolization and Percutaneous Ethanol Injection as an Effective Bridge Therapy before Liver Transplantation for Hepatitis C-Related Hepatocellular Carcinoma
Joint Authors
Alvares-da-Silva, Mario Reis
Scaffaro, Leandro Armani
Kruel, Cleber Dario Pinto
Kruel, Cleber Rosito Pinto
Chedid, Marcio F.
Grezzana-Filho, Tomaz J. M.
Chedid, Aljamir D.
Leipnitz, Ian
Maciel, Antonio C.
Cerski, Carlos Thadeu S.
Reis, Matheus J.
de Araujo, Alexandre
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Transarterial chemoembolization alone or in association with radiofrequency ablation is an effective bridging strategy for patients with hepatocellular carcinoma awaiting for a liver transplant.
However, cost of this therapy may limit its utilization.
This study was designed to evaluate the outcomes of a protocol involving transarterial embolization, percutaneous ethanol injection, or both methods for bridging hepatocellular carcinomas prior to liver transplantation.
Methods.
Retrospective review of all consecutive adult patients who underwent a first liver transplant as a treatment to hepatitis C-related hepatocellular carcinoma at our institution between 2002 and 2012.
Primary endpoint was patient survival.
Secondary endpoint was complete tumor necrosis.
Results.
Forty patients were analyzed, age 58 ± 7 years.
There were 23 males (57.5%).
Thirty-six (90%) out of the total 40 patients were within Milan criteria.
Complete necrosis was achieved in 19 patients (47.5%).
One-, 3-, and 5-year patient survival were, respectively, 87.5%, 75%, and 69.4%.
Univariate analysis did not reveal any variable to impact on overall patient survival.
Conclusions.
Transarterial embolization, ethanol injection, or the association of both methods followed by liver transplantation comprises effective treatment strategy for hepatitis C-related hepatocellular carcinoma.
This strategy should be adopted whenever transarterial chemoembolization and/or radiofrequency ablation are not available options.
American Psychological Association (APA)
Chedid, Marcio F.& Scaffaro, Leandro Armani& Chedid, Aljamir D.& Maciel, Antonio C.& Cerski, Carlos Thadeu S.& Reis, Matheus J.…[et al.]. 2015. Transarterial Embolization and Percutaneous Ethanol Injection as an Effective Bridge Therapy before Liver Transplantation for Hepatitis C-Related Hepatocellular Carcinoma. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1104839
Modern Language Association (MLA)
Chedid, Marcio F.…[et al.]. Transarterial Embolization and Percutaneous Ethanol Injection as an Effective Bridge Therapy before Liver Transplantation for Hepatitis C-Related Hepatocellular Carcinoma. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1104839
American Medical Association (AMA)
Chedid, Marcio F.& Scaffaro, Leandro Armani& Chedid, Aljamir D.& Maciel, Antonio C.& Cerski, Carlos Thadeu S.& Reis, Matheus J.…[et al.]. Transarterial Embolization and Percutaneous Ethanol Injection as an Effective Bridge Therapy before Liver Transplantation for Hepatitis C-Related Hepatocellular Carcinoma. Gastroenterology Research and Practice. 2015. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1104839
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104839