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Interaction of XRCC1 Arg399Gln Polymorphism and Alcohol Consumption Influences Susceptibility of Esophageal Cancer
Joint Authors
Li, Man
Yu, Xia
Zhang, Zhi-yan
Wu, Chun-long
Xu, Hai-long
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-01
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
To explore the correlation between the Arg399Gln polymorphism and susceptibility to esophageal cancer in Korean and Han Chinese individuals in Harbin, China, and its potential interaction with alcohol consumption.
Methods.
This prospective study included 203 patients with esophageal squamous cell carcinoma; 88 were of Korean descent and 115 were of Han Chinese descent.
A group of healthy controls included 105 participants of Korean descent and 105 of Han Chinese descent.
Genotyping of the Arg399Gln locus of XRCC1 was performed by PCR-RFLP.
Results.
The allelic and genotypic frequencies were not significantly different between individuals with esophageal cancer and controls or between individuals of Korean and Han Chinese descent ( P > 0.05 ).
However, when individuals with the wild-type Arg/Arg genotype also consumed alcohol, the risk of esophageal cancer was lower (OR = 3.539; 95% CI = 2.039–6.142; P < 0.05 ).
Conclusions.
The XRCC1 Arg399Gln polymorphism does not appear to be associated with esophageal cancer in individuals of Korean or Han Chinese descent in Harbin, China.
However, alcohol consumption may decrease the risk of esophageal cancer in persons with the wild-type genotype.
American Psychological Association (APA)
Li, Man& Yu, Xia& Zhang, Zhi-yan& Wu, Chun-long& Xu, Hai-long. 2016. Interaction of XRCC1 Arg399Gln Polymorphism and Alcohol Consumption Influences Susceptibility of Esophageal Cancer. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1104842
Modern Language Association (MLA)
Li, Man…[et al.]. Interaction of XRCC1 Arg399Gln Polymorphism and Alcohol Consumption Influences Susceptibility of Esophageal Cancer. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1104842
American Medical Association (AMA)
Li, Man& Yu, Xia& Zhang, Zhi-yan& Wu, Chun-long& Xu, Hai-long. Interaction of XRCC1 Arg399Gln Polymorphism and Alcohol Consumption Influences Susceptibility of Esophageal Cancer. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1104842
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104842