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Risk of Gastrointestinal Bleeding with Rivaroxaban: A Comparative Study with Warfarin
Joint Authors
Husein, Husein
Sulaiman, Samian
Tupper, Ruth
Spurr, Charles
Sifuentes, Humberto
Sridhar, Subbaramiah
Samo, Salih
Sherid, Muhammed
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Introduction.
The risk of gastrointestinal (GI) bleeding with rivaroxaban has not been studied extensively.
The aim of our study was to assess this risk in comparison to warfarin.
Methods.
We examined the medical records for patients who were started on rivaroxaban or warfarin from April 2011 to April 2013.
Results.
We identified 300 patients (147 on rivaroxaban versus 153 on warfarin).
GI bleeding occurred in 4.8% patients with rivaroxaban when compared to 9.8% patients in warfarin group (p=0.094).
GI bleeding occurred in 8% with therapeutic doses of rivaroxaban (>10 mg/d) compared to 9.8% with warfarin (p=0.65).
Multivariate analysis showed that patients who were on rivaroxaban for ≤40 days had a higher incidence of GI bleeding than those who were on it for >40 days (OR = 2.8, p=0.023).
Concomitant use of dual antiplatelet agents was associated with increased risk of GI bleeding in the rivaroxaban group (OR = 7.4, p=0.0378).
Prior GI bleeding was also a risk factor for GI bleeding in rivaroxaban group (OR = 15.5).
Conclusion.
The incidence of GI bleeding was similar between rivaroxaban and warfarin.
The risk factors for GI bleeding with rivaroxaban were the first 40 days of taking the drug, concomitant dual antiplatelet agents, and prior GI bleeding.
American Psychological Association (APA)
Sherid, Muhammed& Sulaiman, Samian& Samo, Salih& Husein, Husein& Tupper, Ruth& Spurr, Charles…[et al.]. 2016. Risk of Gastrointestinal Bleeding with Rivaroxaban: A Comparative Study with Warfarin. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104844
Modern Language Association (MLA)
Sherid, Muhammed…[et al.]. Risk of Gastrointestinal Bleeding with Rivaroxaban: A Comparative Study with Warfarin. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1104844
American Medical Association (AMA)
Sherid, Muhammed& Sulaiman, Samian& Samo, Salih& Husein, Husein& Tupper, Ruth& Spurr, Charles…[et al.]. Risk of Gastrointestinal Bleeding with Rivaroxaban: A Comparative Study with Warfarin. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104844
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104844