Differential Impacts of Soybean and Fish Oils on Hepatocyte Lipid Droplet Accumulation and Endoplasmic Reticulum Stress in Primary Rabbit Hepatocytes
Joint Authors
Zhu, Xueping
Xu, Yumin
Cheng, Ping
Xiao, Zhihui
Zhao, Xingli
Cui, Ningxun
Cui, Mingling
Li, Jie
Zhu, Xiaoli
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Parenteral nutrition-associated liver disease (PNALD) is a severe ailment associated with long-term parenteral nutrition.
Soybean oil-based lipid emulsions (SOLE) are thought to promote PNALD development, whereas fish oil-based lipid emulsions (FOLE) are thought to protect against PNALD.
This study aimed to investigate the effects of SOLE and FOLE on primary rabbit hepatocytes.
The results reveal that SOLE caused significant endoplasmic reticulum (ER) and mitochondrial damage, ultimately resulting in lipid droplets accumulation and ER stress.
While these deleterious events induce hepatocyte injury, FOLE at high doses cause only minor ER and mitochondrial damage, which has no effect on hepatic function.
SOLE also significantly upregulated glucose-regulated protein 94 mRNA and protein expression.
These data indicate that SOLE, but not FOLE, damage the ER and mitochondria, resulting in lipid droplets accumulation and ER stress and, finally, hepatocyte injury.
This likely contributes to the differential impacts of SOLE and FOLE on PNALD development and progression.
American Psychological Association (APA)
Zhu, Xueping& Xiao, Zhihui& Xu, Yumin& Zhao, Xingli& Cheng, Ping& Cui, Ningxun…[et al.]. 2016. Differential Impacts of Soybean and Fish Oils on Hepatocyte Lipid Droplet Accumulation and Endoplasmic Reticulum Stress in Primary Rabbit Hepatocytes. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104855
Modern Language Association (MLA)
Zhu, Xueping…[et al.]. Differential Impacts of Soybean and Fish Oils on Hepatocyte Lipid Droplet Accumulation and Endoplasmic Reticulum Stress in Primary Rabbit Hepatocytes. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1104855
American Medical Association (AMA)
Zhu, Xueping& Xiao, Zhihui& Xu, Yumin& Zhao, Xingli& Cheng, Ping& Cui, Ningxun…[et al.]. Differential Impacts of Soybean and Fish Oils on Hepatocyte Lipid Droplet Accumulation and Endoplasmic Reticulum Stress in Primary Rabbit Hepatocytes. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104855
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104855