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Pretreatment Lymphocyte Monocyte Ratio Predicts Long-Term Outcomes in Patients with Digestive System Tumor: A Meta-Analysis
Joint Authors
Zhou, Rui
Liao, Yulin
Liao, Wangjun
Zhang, Jingwen
Chen, Lishan
Sun, Huiying
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Purpose.
The prognostic value of pretreatment lymphocyte monocyte ratio (LMR) in digestive system cancer patients remains controversial.
The aim of this study was to quantify the prognostic impact of this biomarker and assess its consistency in digestive system tumors.
Methods.
We searched “PubMed,” “Embase,” and “CBM” for published eligible studies before June 2016 and conducted a meta-analysis to estimate the pooled hazard ratios (HRs) for disease recurrence and mortality focusing on LMR.
Subgroup analyses, meta-regression, and sensitivity analyses were also performed.
Results.
A total of 22 cohort studies enrolling 12829 patients with digestive system cancer were included.
The summary results showed that lower LMR was significantly associated with worse overall survival (OS), cancer-specific survival (CSS), and tumor disease or recurrence-free survival (DFS/RFS) in analyses using the studies reporting HRs either by the univariate analyses (HR = 1.32, HR = 1.35, and HR = 1.26 for OS, CSS, and DFS/RFS, resp.) or by multivariate analyses (HR = 1.21, HR = 1.18, and HR = 1.26 for OS, CSS, and DFS/RFS, resp.).
Conclusion.
Our results support the fact that decreased LMR indicates worse prognosis in multiple digestive system tumors.
American Psychological Association (APA)
Zhang, Jingwen& Chen, Lishan& Zhou, Rui& Sun, Huiying& Liao, Yulin& Liao, Wangjun. 2016. Pretreatment Lymphocyte Monocyte Ratio Predicts Long-Term Outcomes in Patients with Digestive System Tumor: A Meta-Analysis. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104859
Modern Language Association (MLA)
Zhang, Jingwen…[et al.]. Pretreatment Lymphocyte Monocyte Ratio Predicts Long-Term Outcomes in Patients with Digestive System Tumor: A Meta-Analysis. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1104859
American Medical Association (AMA)
Zhang, Jingwen& Chen, Lishan& Zhou, Rui& Sun, Huiying& Liao, Yulin& Liao, Wangjun. Pretreatment Lymphocyte Monocyte Ratio Predicts Long-Term Outcomes in Patients with Digestive System Tumor: A Meta-Analysis. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104859
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104859