Multianalytical Method Validation for Qualitative and Quantitative Analysis of Solvents of Abuse in Oral Fluid by HS-GCMS
Joint Authors
Pechansky, Flavio
Coppe, Bruna Claudia
Borille, Bruna Tassi
Fiorentin, Taís Regina
Jacques, Ana Laura Bemvenuti
Fagundes, Ana Claudia
Castro, Stela Maris de Jezus
Remy, Lysa Silveira
Limberger, Renata Pereira
Source
International Journal of Analytical Chemistry
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The use of oral fluid as a biological matrix to monitor the use of drugs of abuse is a global trend because it presents several advantages and good correlation to the blood level.
Thus, the present work aimed to develop and validate an analytical method for quantification and detection of solvents used as inhalants of abuse in oral fluid (OF), using Quantisal™ as collector device by headspace and gas chromatography coupled with a mass detector (HS-GC/MS).
Chromatographic separation was performed with a ZB-BAC1 column and the total time of analysis was 11.8 min.
The method showed good linearity (correlation coefficient higher than 0.99 for all solvents).
The limits of detection ranged from 0.05 to 5 mg/L, while the lower limits of quantification ranged from 2.5 to 12.5 mg/L.
Accuracy, precision, matrix effect, and residual effect presented satisfactory results, meeting the criteria accepted for the validation of bioanalytical methods.
The method showed good selectivity considering that, for solvents coeluting at the same retention time, resolution was performed by the mass detector.
The method developed proved to be adequate when applied in OF samples from users of drugs and may be used to monitor the abuse of inhalants in routine forensic analyses.
American Psychological Association (APA)
Coppe, Bruna Claudia& Borille, Bruna Tassi& Fiorentin, Taís Regina& Jacques, Ana Laura Bemvenuti& Fagundes, Ana Claudia& Castro, Stela Maris de Jezus…[et al.]. 2016. Multianalytical Method Validation for Qualitative and Quantitative Analysis of Solvents of Abuse in Oral Fluid by HS-GCMS. International Journal of Analytical Chemistry،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104926
Modern Language Association (MLA)
Coppe, Bruna Claudia…[et al.]. Multianalytical Method Validation for Qualitative and Quantitative Analysis of Solvents of Abuse in Oral Fluid by HS-GCMS. International Journal of Analytical Chemistry No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104926
American Medical Association (AMA)
Coppe, Bruna Claudia& Borille, Bruna Tassi& Fiorentin, Taís Regina& Jacques, Ana Laura Bemvenuti& Fagundes, Ana Claudia& Castro, Stela Maris de Jezus…[et al.]. Multianalytical Method Validation for Qualitative and Quantitative Analysis of Solvents of Abuse in Oral Fluid by HS-GCMS. International Journal of Analytical Chemistry. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104926
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104926