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The Role of Forkhead Box Protein M1 in Breast Cancer Progression and Resistance to Therapy
Joint Authors
Saba, Raya
Alsayed, Alhareth
Zacny, James P.
Dudek, Arkadiusz Z.
Source
International Journal of Breast Cancer
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The Forkhead box M1 (FOXM1) is a transcription factor that has been implicated in normal cell growth and proliferation through control of cell cycle transition and mitotic spindle.
It is implicated in carcinogenesis of various malignancies where it is activated by either amplification, increased stability, enhanced transcription, dysfunction of regulatory pathways, or activation of PI3K/AKT, epidermal growth factor receptor, Raf/MEK/MAPK, and Hedgehog pathways.
This review describes the role of FOXM1 in breast cancer.
This includes how FOXM1 impacts on different subtypes of breast cancer, that is, luminal/estrogen receptor positive (ER+), expressing human epidermal growth factor receptor 2 (HER2), basal-like breast cancer (BBC), and triple negative breast cancer (TNBC).
The review also describes different tested preclinical therapeutic strategies targeting FOXM1.
Developing clinically applicable therapies that specifically inhibit FOXM1 activity is a logical next step in biomarker-driven approaches against breast cancer but will not be without its challenges due to the unique properties of this transcription factor.
American Psychological Association (APA)
Saba, Raya& Alsayed, Alhareth& Zacny, James P.& Dudek, Arkadiusz Z.. 2016. The Role of Forkhead Box Protein M1 in Breast Cancer Progression and Resistance to Therapy. International Journal of Breast Cancer،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1105405
Modern Language Association (MLA)
Saba, Raya…[et al.]. The Role of Forkhead Box Protein M1 in Breast Cancer Progression and Resistance to Therapy. International Journal of Breast Cancer No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1105405
American Medical Association (AMA)
Saba, Raya& Alsayed, Alhareth& Zacny, James P.& Dudek, Arkadiusz Z.. The Role of Forkhead Box Protein M1 in Breast Cancer Progression and Resistance to Therapy. International Journal of Breast Cancer. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1105405
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105405