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Liposomal Systems as Nanocarriers for the Antiviral Agent Ivermectin
Joint Authors
Nastruzzi, Claudio
Croci, Romina
Bottaro, Elisabetta
Chan, Kitti Wing Ki
Watanabe, Satoru
Pezzullo, Margherita
Mastrangelo, Eloise
Source
International Journal of Biomaterials
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-08
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
RNA virus infections can lead to the onset of severe diseases such as fever with haemorrhage, multiorgan failure, and mortality.
The emergence and reemergence of RNA viruses continue to pose a significant public health threat worldwide with particular attention to the increasing incidence of flaviviruses, among others Dengue, West Nile Virus, and Yellow Fever viruses.
Development of new and potent antivirals is thus urgently needed.
Ivermectin, an already known antihelminthic drug, has shown potent effects in vitro on Flavivirus helicase, with EC50 values in the subnanomolar range for Yellow Fever and submicromolar EC50 for Dengue Fever, Japanese encephalitis, and tick-borne encephalitis viruses.
However ivermectin is hampered in its application by pharmacokinetic problems (little solubility and high cytotoxicity).
To overcome such problems we engineered different compositions of liposomes as ivermectin carriers characterizing and testing them on several cell lines for cytotoxicity.
The engineered liposomes were less cytotoxic than ivermectin alone and they showed a significant increase of the antiviral activity in all the Dengue stains tested (1, 2, and S221).
In the current study ivermectin is confirmed to be an effective potential antiviral and liposomes, as drug carriers, are shown to modulate the drug activity.
All together the results represent a promising starting point for future improvement of ivermectin as antiviral and its delivery.
American Psychological Association (APA)
Croci, Romina& Bottaro, Elisabetta& Chan, Kitti Wing Ki& Watanabe, Satoru& Pezzullo, Margherita& Mastrangelo, Eloise…[et al.]. 2016. Liposomal Systems as Nanocarriers for the Antiviral Agent Ivermectin. International Journal of Biomaterials،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1105469
Modern Language Association (MLA)
Croci, Romina…[et al.]. Liposomal Systems as Nanocarriers for the Antiviral Agent Ivermectin. International Journal of Biomaterials No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1105469
American Medical Association (AMA)
Croci, Romina& Bottaro, Elisabetta& Chan, Kitti Wing Ki& Watanabe, Satoru& Pezzullo, Margherita& Mastrangelo, Eloise…[et al.]. Liposomal Systems as Nanocarriers for the Antiviral Agent Ivermectin. International Journal of Biomaterials. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1105469
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105469