Influence of Type 2 Diabetes on Prevalence of Key Periodontal Pathogens, Salivary Matrix Metalloproteinases, and Bone Remodeling Markers in Sudanese Adults with and without Chronic Periodontitis
Joint Authors
Mohamed, Hasaan Gassim
Idris, Shaza Bushra
Mustafa, Manal
Ahmed, Mutaz Faisal
Åstrøm, Anne Nordrehaug
Mustafa, Kamal
Ibrahim, Salah Osman
Source
International Journal of Dentistry
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This study compared the influence of type 2 diabetes on the occurrence of six periodontal pathogens in plaque samples of patients with and without chronic periodontitis.
Levels of salivary MMP-8, MMP-9, RANKL, and OPG were also investigated.
The study enrolled 31 patients with type 2 diabetes and chronic periodontitis (DM + CP), 29 with chronic periodontitis (CP), and 20 with type 2 diabetes (DM).
Questionnaire-guided interviews were conducted and plaque index, bleeding on probing, and pocket depth were recorded.
Polymerase chain reaction (PCR) was utilized to determine the prevalence of the bacteria.
The levels of salivary molecules were determined by enzyme immunosorbent assay (ELISA).
The CP group had the highest prevalence of P.
gingivalis (81.5%), followed by the DM + CP (59.3%) and DM (55.0%) groups ( P > 0.05 ).
Similar trends were observed for P.
intermedia and T.
denticola.
The prevalence of T.
forsythia was 100% in both periodontitis groups compared to 90% in the DM group.
There were no significant differences between the groups regarding the concentrations of MMP-8, MMP-9, or OPG.
RANKL concentrations were below the detection limit.
Our data show that type 2 diabetes has no significant influence on the prevalence of the investigated periodontal pathogens, or the levels of salivary MMP-8, MMP-9, and OPG.
American Psychological Association (APA)
Mohamed, Hasaan Gassim& Idris, Shaza Bushra& Mustafa, Manal& Ahmed, Mutaz Faisal& Åstrøm, Anne Nordrehaug& Mustafa, Kamal…[et al.]. 2016. Influence of Type 2 Diabetes on Prevalence of Key Periodontal Pathogens, Salivary Matrix Metalloproteinases, and Bone Remodeling Markers in Sudanese Adults with and without Chronic Periodontitis. International Journal of Dentistry،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1105643
Modern Language Association (MLA)
Mohamed, Hasaan Gassim…[et al.]. Influence of Type 2 Diabetes on Prevalence of Key Periodontal Pathogens, Salivary Matrix Metalloproteinases, and Bone Remodeling Markers in Sudanese Adults with and without Chronic Periodontitis. International Journal of Dentistry No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1105643
American Medical Association (AMA)
Mohamed, Hasaan Gassim& Idris, Shaza Bushra& Mustafa, Manal& Ahmed, Mutaz Faisal& Åstrøm, Anne Nordrehaug& Mustafa, Kamal…[et al.]. Influence of Type 2 Diabetes on Prevalence of Key Periodontal Pathogens, Salivary Matrix Metalloproteinases, and Bone Remodeling Markers in Sudanese Adults with and without Chronic Periodontitis. International Journal of Dentistry. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1105643
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105643