Experimentally Induced Pulpal Lesion and Substance P Expression: Effect of Ketoprofen—A Preliminary Study
Joint Authors
Mangano, Alessandro
Amodeo, Giada
Sacerdote, Paola
Abbate, G. M.
Levrini, L.
Source
International Journal of Dentistry
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-29
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objectives.
To evaluate substance P (SP) and the effect of ketoprofen administration, a nonsteroidal anti-inflammatory drug (NSAID), on SP in the pulp of upper third molars with experimentally induced pulpal lesion.
Materials and Methods.
A sample of 20 young systemically healthy adults of both sexes, nonsmokers, with a healthy upper third molar to extract for orthodontic purposes, was selected.
Prior to the procedure, an inflammatory process was generated by mechanical exposure of the pulp.
After 15 minutes, the pulp was collected using a sterile barbed broach.
SP levels were determined by using a commercially available enzyme immunoassay (ELISA) kit.
The subjects were randomly divided into two groups: group 1 received a dose of ketoprofen 30 minutes prior to the experimental procedure.
The subjects of group 2 did not receive any kind of drug administration.
The patients were asked to complete a diary on the postoperative pain.
Results.
No statistically significant difference could be detected in SP expression between the two groups.
In group 1, pain manifestation was significantly delayed in comparison with group 2.
Conclusions.
Preventive administration of ketoprofen did not significantly affect the pulpal levels of SP but resulted in a significantly postponed manifestation of pain after extraction.
American Psychological Association (APA)
Abbate, G. M.& Sacerdote, Paola& Amodeo, Giada& Mangano, Alessandro& Levrini, L.. 2016. Experimentally Induced Pulpal Lesion and Substance P Expression: Effect of Ketoprofen—A Preliminary Study. International Journal of Dentistry،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1105645
Modern Language Association (MLA)
Abbate, G. M.…[et al.]. Experimentally Induced Pulpal Lesion and Substance P Expression: Effect of Ketoprofen—A Preliminary Study. International Journal of Dentistry No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1105645
American Medical Association (AMA)
Abbate, G. M.& Sacerdote, Paola& Amodeo, Giada& Mangano, Alessandro& Levrini, L.. Experimentally Induced Pulpal Lesion and Substance P Expression: Effect of Ketoprofen—A Preliminary Study. International Journal of Dentistry. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1105645
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105645