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Differential Role of Adipose Tissues in Obesity and Related Metabolic and Vascular Complications
Joint Authors
Gómez-Hernández, Almudena
Beneit, Nuria
Díaz-Castroverde, Sabela
Escribano, Óscar
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-27
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
This review focuses on the contribution of white, brown, and perivascular adipose tissues to the pathophysiology of obesity and its associated metabolic and vascular complications.
Weight gain in obesity generates excess of fat, usually visceral fat, and activates the inflammatory response in the adipocytes and then in other tissues such as liver.
Therefore, low systemic inflammation responsible for insulin resistance contributes to atherosclerotic process.
Furthermore, an inverse relationship between body mass index and brown adipose tissue activity has been described.
For these reasons, in recent years, in order to combat obesity and its related complications, as a complement to conventional treatments, a new insight is focusing on the role of the thermogenic function of brown and perivascular adipose tissues as a promising therapy in humans.
These lines of knowledge are focused on the design of new drugs, or other approaches, in order to increase the mass and/or activity of brown adipose tissue or the browning process of beige cells from white adipose tissue.
These new treatments may contribute not only to reduce obesity but also to prevent highly prevalent complications such as type 2 diabetes and other vascular alterations, such as hypertension or atherosclerosis.
American Psychological Association (APA)
Gómez-Hernández, Almudena& Beneit, Nuria& Díaz-Castroverde, Sabela& Escribano, Óscar. 2016. Differential Role of Adipose Tissues in Obesity and Related Metabolic and Vascular Complications. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1105754
Modern Language Association (MLA)
Gómez-Hernández, Almudena…[et al.]. Differential Role of Adipose Tissues in Obesity and Related Metabolic and Vascular Complications. International Journal of Endocrinology No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1105754
American Medical Association (AMA)
Gómez-Hernández, Almudena& Beneit, Nuria& Díaz-Castroverde, Sabela& Escribano, Óscar. Differential Role of Adipose Tissues in Obesity and Related Metabolic and Vascular Complications. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1105754
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105754