Vitamin D Status Is Negatively Correlated with Insulin Resistance in Chinese Type 2 Diabetes

Abstract EN

Objectives.

Vitamin D deficiency plays a role in insulin resistance and the pathogenesis of type 2 diabetes mellitus.

Little information is available about the association between vitamin D status and insulin resistance in the Chinese population.

Currently, vitamin D status is evaluated by the concentrations of serum 25-hydroxyvitamin D [25(OH)D].

This study explores the relationship between insulin resistance and serum 25-hydroxyvitamin D concentrations in Chinese patients with type 2 diabetes mellitus.

Subjects and Methods.

This study included 117 patients with type 2 diabetes.

The following variables were measured: 25-hydroxyvitamin D [25(OH)D], glycosylated hemoglobin A1c (HbA1c), fasting blood glucose (FBS), fasting blood insulin (FINS), fasting blood C-peptide, serum creatinine (SCr), glomerular filtration rate (eGFR), body mass index (BMI), and homeostatic model estimates of insulin resistance (HOMA-IR).

Results.

The cases were divided into three groups: Group 1 (G1) with 25(OH)D ≤ 20 ng/mL [≤50 nmol/L], Group 2 (G2) with 25(OH)D values from 20 ng/mL [50 nmol/L] to 30 ng/mL [75 nmol/L], and Group 3 (G3) with 25(OH)D ≥ 30 ng/mL [≥75 nmol/L], with 52.6%, 26.3%, and 21.1% of subjects in Groups 1–3, respectively.

There was a negative correlation between 25(OH)D and HOMA-IR ( β = −0.314, p = 0.001 ) adjusted by age, BMI, and eGFR.

Conclusion.

Better vitamin D status may be protective of glucose homeostasis since 25(OH)D was negatively associated with insulin resistance in Chinese patients with type 2 diabetes.