Inositols in the Treatment of Insulin-Mediated Diseases

Abstract EN

A growing body of research is currently focused on the role of inositol isomers and in particular myo-inositol (MYO-INS) and D-chiroinositol (DCI) in the treatment of insulin resistance states.

Both isomers have been shown to exert insulin-mimetic action and to lower postprandial glucose.

Further, insulin resistance-related diseases were associated to derangements in inositol metabolism.

Thus, the aim of this review is to provide current evidence on the potential benefits of inositol isomers (MYO-INS and DCI) in the treatment of disease associated to insulin resistance such as polycystic ovary syndrome (PCOS), gestational diabetes, and metabolic syndrome.

Finally, molecular insights into inositol insulin-sensitizing effects will be covered focusing on the possible role of inositol glycans as insulin second messengers.