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The Effect of Levothyroxine Discontinuation Timing on Postoperative Hypothyroidism after Hemithyroidectomy for Papillary Thyroid Microcarcinoma
Joint Authors
Kim, Dong Wook
Park, Young Mi
Ha, Tae Kwun
Park, Ha Kyoung
Baek, Jin Wook
Lee, Yoo Jin
Kim, Do Hun
Jung, Soo Jin
Ahn, Ki Jung
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
No previous studies regarding the appropriate timing of thyroid hormone discontinuation after hemithyroidectomy have been published.
This study aimed to identify the appropriate timing for levothyroxine discontinuation after hemithyroidectomy among patients with papillary thyroid microcarcinoma (PTMC).
Methods.
This study retrospectively evaluated 304 patients who underwent ≥1 attempt to discontinue levothyroxine after hemithyroidectomy for treating PTMC between January 2008 and December 2013.
Fifty-three patients were excluded because of preoperative hypothyroidism or hyperthyroidism, a history of thyroid hormone or antithyroid therapy, no available serological data, or a postoperative follow-up of <24 months.
We evaluated the associations of successful levothyroxine discontinuation with patient age, sex, preoperative serological data, underlying thyroid gland histopathology, anteroposterior diameter of the residual thyroid gland, number of discontinuation attempts, and initial discontinuation timing.
Results.
Among the 251 included patients, 125 patients (49.8%) achieved successful levothyroxine discontinuation during the follow-up period after hemithyroidectomy.
There was a significant difference in the outcomes for patients who underwent an initial discontinuation attempt at ≤3 months and ≥4 months after hemithyroidectomy (p < 0.001).
There were significant differences in the discontinuation outcomes according to underlying thyroid histopathology (p = 0.001), preoperative thyroid-stimulating hormone levels (p < 0.001), and number of discontinuation attempts (p < 0.001).
Conclusions.
Among patients with PTMC, the initial levothyroxine discontinuation attempt is recommended at ≥4 months after hemithyroidectomy.
American Psychological Association (APA)
Ha, Tae Kwun& Kim, Dong Wook& Park, Ha Kyoung& Baek, Jin Wook& Lee, Yoo Jin& Park, Young Mi…[et al.]. 2016. The Effect of Levothyroxine Discontinuation Timing on Postoperative Hypothyroidism after Hemithyroidectomy for Papillary Thyroid Microcarcinoma. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1105847
Modern Language Association (MLA)
Ha, Tae Kwun…[et al.]. The Effect of Levothyroxine Discontinuation Timing on Postoperative Hypothyroidism after Hemithyroidectomy for Papillary Thyroid Microcarcinoma. International Journal of Endocrinology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1105847
American Medical Association (AMA)
Ha, Tae Kwun& Kim, Dong Wook& Park, Ha Kyoung& Baek, Jin Wook& Lee, Yoo Jin& Park, Young Mi…[et al.]. The Effect of Levothyroxine Discontinuation Timing on Postoperative Hypothyroidism after Hemithyroidectomy for Papillary Thyroid Microcarcinoma. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1105847
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105847