Estimation of the Relative Contribution of Postprandial Glucose Exposure to Average Total Glucose Exposure in Subjects with Type 2 Diabetes
Joint Authors
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-18
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
We hypothesized that the relative contribution of fasting plasma glucose (FPG) versus postprandial plasma glucose (PPG) to glycated haemoglobin (HbA1c) could be calculated using an algorithm developed by the A1c-Derived Average Glucose (ADAG) study group to make HbA1c values more clinically relevant to patients.
The algorithm estimates average glucose (eAG) exposure, which can be used to calculate apparent PPG (aPPG) by subtracting FPG.
The hypothesis was tested in a large dataset (comprising 17 studies) from the vildagliptin clinical trial programme.
We found that 24 weeks of treatment with vildagliptin monotherapy ( n = 2523 ) reduced the relative contribution of aPPG to eAG from 8.12% to 2.95% (by 64%, p < 0.001 ).
In contrast, when vildagliptin was added to metformin ( n = 2752 ), the relative contribution of aPPG to eAG insignificantly increased from 1.59% to 2.56%.
In conclusion, glucose peaks, which are often prominent in patients with type 2 diabetes, provide a small contribution to the total glucose exposure assessed by HbA1c, and the ADAG algorithm is not robust enough to assess this small relative contribution in patients receiving combination therapy.
American Psychological Association (APA)
Ahrén, Bo& Foley, James E.. 2016. Estimation of the Relative Contribution of Postprandial Glucose Exposure to Average Total Glucose Exposure in Subjects with Type 2 Diabetes. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1105858
Modern Language Association (MLA)
Ahrén, Bo& Foley, James E.. Estimation of the Relative Contribution of Postprandial Glucose Exposure to Average Total Glucose Exposure in Subjects with Type 2 Diabetes. International Journal of Endocrinology No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1105858
American Medical Association (AMA)
Ahrén, Bo& Foley, James E.. Estimation of the Relative Contribution of Postprandial Glucose Exposure to Average Total Glucose Exposure in Subjects with Type 2 Diabetes. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1105858
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105858