Trimester- and Assay-Specific Thyroid Reference Intervals for Pregnant Women in China
Joint Authors
Xing, Jinfang
Yuan, Enwu
Li, Jing
Zhang, Yuchao
Meng, Xiangying
Zhang, Xia
Rong, Shouhua
Lv, Zhongxing
Tian, Yuan
Jia, Liting
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-21
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
The guidelines of the American Thyroid Association (ATA) recommend an upper limit reference interval (RI) of thyroid stimulating hormone (TSH) of 2.5 mIU/L in the first trimester of pregnancy and 3.0 mIU/L in subsequent trimesters, but some reported ranges in China are significantly higher.
Our study aimed to establish trimester- and assay-specific RIs for thyroid hormones in normal pregnant Chinese women.
Methods.
In this cross-sectional study, 2540 women with normal pregnancies (first trimester, n = 398 ; second trimester, n = 797 ; third trimester, n = 1345 ) and 237 healthy nonpregnant control subjects were recruited.
Serum TSH, free thyroxin (FT4), thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb) levels were determined by automated chemiluminescence with an Immulite 2000 system (Siemens, Erlangen, Germany).
After outliers were excluded, the 2.5–97.5th percentiles were used to define the RIs.
Results.
The RIs of thyroid function in the first, second, and third trimesters of pregnancy and in nonpregnant controls were 0.07–3.96, 0.27–4.53, 0.48–5.40, and 0.69–5.78 mIU/L for TSH and 9.16–18.12, 8.67–16.21, 7.80–13.90, and 8.24–16.61 pmol/L for FT4, respectively.
Conclusion.
The trimester- and assay-specific RIs of thyroid function during pregnancy differed between trimesters, which suggests that it is advisable to detect and avoid misclassification of thyroid dysfunction during pregnancy for women in Henan, China.
American Psychological Association (APA)
Xing, Jinfang& Yuan, Enwu& Li, Jing& Zhang, Yuchao& Meng, Xiangying& Zhang, Xia…[et al.]. 2016. Trimester- and Assay-Specific Thyroid Reference Intervals for Pregnant Women in China. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1105860
Modern Language Association (MLA)
Xing, Jinfang…[et al.]. Trimester- and Assay-Specific Thyroid Reference Intervals for Pregnant Women in China. International Journal of Endocrinology No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1105860
American Medical Association (AMA)
Xing, Jinfang& Yuan, Enwu& Li, Jing& Zhang, Yuchao& Meng, Xiangying& Zhang, Xia…[et al.]. Trimester- and Assay-Specific Thyroid Reference Intervals for Pregnant Women in China. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1105860
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105860