Prenatal and Childhood Growth, Chemerin Concentrations, and Metabolic Health in Adult Life
Joint Authors
Osmond, Clive
Eriksson, Johan G.
Venojärvi, M.
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Several noncommunicable diseases have their origins in early developmental phases.
One factor possibly explaining the association between early growth and later health could be adipocyte function.
The objective of this study was to assess the association between the adipocytokine chemerin and early growth and later health.
1074 participants from Helsinki Birth Cohort Study born 1934–1944 with information on prenatal and childhood growth participated.
Metabolic outcomes include glucose tolerance, adiposity, and chemerin concentration.
Mean chemerin concentrations were 5.0 ng/mL higher in women than in men (95% CI 2.7 to 7.2, p<0.001).
The strongest correlate of chemerin concentration was adult waist circumference and body fat percentage (r=0.22, p<0.001 and r=0.21, p<0.001, resp.).
After adjustment for body fat percentage, chemerin concentration was 5.4 ng/mL lower in subjects with type 2 diabetes than in those with normal glucose tolerance (−0.2 to 10.9, p=0.06).
It was 3.0 ng/mL higher in those with metabolic syndrome than in those without (0.6 to 5.3, p=0.01).
No measure of early growth was associated with chemerin concentration.
Our findings do not support a role for chemerin in linking early growth with later metabolic health.
American Psychological Association (APA)
Eriksson, Johan G.& Venojärvi, M.& Osmond, Clive. 2016. Prenatal and Childhood Growth, Chemerin Concentrations, and Metabolic Health in Adult Life. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1105865
Modern Language Association (MLA)
Eriksson, Johan G.…[et al.]. Prenatal and Childhood Growth, Chemerin Concentrations, and Metabolic Health in Adult Life. International Journal of Endocrinology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1105865
American Medical Association (AMA)
Eriksson, Johan G.& Venojärvi, M.& Osmond, Clive. Prenatal and Childhood Growth, Chemerin Concentrations, and Metabolic Health in Adult Life. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1105865
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105865