Disproportionately Elevated Proinsulin Levels as an Early Indicator of β-Cell Dysfunction in Nondiabetic Offspring of Chinese Diabetic Patients
Joint Authors
Li, Ming
Feng, Dan
Zhang, Kui
Gao, Shan
Lu, Juming
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To study the characteristics of β-cell dysfunction and insulin resistance (IR) in the first-degree relatives (FDRs) of T2DM in Chinese population and to examine the usefulness of proinsulin (PI) for evaluating β-cell dysfunction.
Methods.
229 subjects of nondiabetic FDRs, 71 newly diagnosed T2DM, and 114 with normal glucose tolerance (NGT) but not FDRs (NGT-non-FDRs) were verified by a 2-hour oral glucose tolerance test.
Specific insulin (SI) and PI were measured by highly sensitive ELISA.
Results.
Compared to NGT-non-FDRs, NGT-FDRs showed higher levels of fasting and 2-hour PI, fasting PI-to-SI ratio (FPI/SI), and HOMA-IR ( p < 0.01 ).
Meanwhile, fasting PI, FPI/SI, and HOMA-IR were increased steadily from NGT-FDRs to prediabetes-FDRs and were highest in T2DM group ( p < 0.001 ), whereas a significant decrease in HOMA-B could be observed only in T2DM group.
Moreover, a progressive deterioration of β-cell function in NGT-FDRs, prediabetes-FDRs, and T2DM could be identified by FPI/SI even after adjusting for HOMA-IR: relative to non-FDRs controls, mean FPI/SI levels were increased 1.5, 2.0, and 4.7-fold, respectively (all p < 0.01 ).
Conclusions.
β-cell dysfunction as assessed by disproportionate secretion of proinsulin and IR by HOMA (using specific insulin assay) already exist in FDRs of T2DM even with normal glucose status.
Compared with HOMA-B, FPI/SI could detect β-cell failure in earlier stage of diabetes development.
American Psychological Association (APA)
Li, Ming& Feng, Dan& Zhang, Kui& Gao, Shan& Lu, Juming. 2016. Disproportionately Elevated Proinsulin Levels as an Early Indicator of β-Cell Dysfunction in Nondiabetic Offspring of Chinese Diabetic Patients. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1105896
Modern Language Association (MLA)
Li, Ming…[et al.]. Disproportionately Elevated Proinsulin Levels as an Early Indicator of β-Cell Dysfunction in Nondiabetic Offspring of Chinese Diabetic Patients. International Journal of Endocrinology No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1105896
American Medical Association (AMA)
Li, Ming& Feng, Dan& Zhang, Kui& Gao, Shan& Lu, Juming. Disproportionately Elevated Proinsulin Levels as an Early Indicator of β-Cell Dysfunction in Nondiabetic Offspring of Chinese Diabetic Patients. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1105896
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105896