![](/images/graphics-bg.png)
How to Achieve High-Quality Oocytes? The Key Role of Myo-Inositol and Melatonin
Joint Authors
Corrado, F.
Vitale, Salvatore Giovanni
Rapisarda, Agnese Maria Chiara
Rossetti, Paola
Valenti, Gaetano
Sapia, Fabrizio
Buscema, Massimo
Lagana, Antonio Simone
Condorelli, Rosita A.
La Vignera, Sandro
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Assisted reproductive technologies (ART) have experienced growing interest from infertile patients seeking to become pregnant.
The quality of oocytes plays a pivotal role in determining ART outcomes.
Although many authors have studied how supplementation therapy may affect this important parameter for both in vivo and in vitro models, data are not yet robust enough to support firm conclusions.
Regarding this last point, in this review our objective has been to evaluate the state of the art regarding supplementation with melatonin and myo-inositol in order to improve oocyte quality during ART.
On the one hand, the antioxidant effect of melatonin is well known as being useful during ovulation and oocyte incubation, two occasions with a high level of oxidative stress.
On the other hand, myo-inositol is important in cellular structure and in cellular signaling pathways.
Our analysis suggests that the use of these two molecules may significantly improve the quality of oocytes and the quality of embryos: melatonin seems to raise the fertilization rate, and myo-inositol improves the pregnancy rate, although all published studies do not fully agree with these conclusions.
However, previous studies have demonstrated that cotreatment improves these results compared with melatonin alone or myo-inositol alone.
We recommend that further studies be performed in order to confirm these positive outcomes in routine ART treatment.
American Psychological Association (APA)
Vitale, Salvatore Giovanni& Rossetti, Paola& Corrado, F.& Rapisarda, Agnese Maria Chiara& La Vignera, Sandro& Condorelli, Rosita A.…[et al.]. 2016. How to Achieve High-Quality Oocytes? The Key Role of Myo-Inositol and Melatonin. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1105901
Modern Language Association (MLA)
Vitale, Salvatore Giovanni…[et al.]. How to Achieve High-Quality Oocytes? The Key Role of Myo-Inositol and Melatonin. International Journal of Endocrinology No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1105901
American Medical Association (AMA)
Vitale, Salvatore Giovanni& Rossetti, Paola& Corrado, F.& Rapisarda, Agnese Maria Chiara& La Vignera, Sandro& Condorelli, Rosita A.…[et al.]. How to Achieve High-Quality Oocytes? The Key Role of Myo-Inositol and Melatonin. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1105901
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105901