GC Gene Polymorphisms and Vitamin D-Binding Protein Levels Are Related to the Risk of Generalized Aggressive Periodontitis
Joint Authors
Meng, Huanxin
Song, Wenli
Wang, Xian’e
Tian, Yu
Zhang, Xin
Lu, Ruifang
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To explore whether GC (group-specific component) rs17467825, rs4588, and rs7041 polymorphisms are associated with generalized aggressive periodontitis.
Methods.
This case-control study recruited 372 patients with generalized aggressive periodontitis (group AgP) and 133 periodontal healthy subjects (group HP).
GC rs17467825, rs4588, and rs7041 genotypes and plasmatic vitamin D-binding protein (DBP) were measured.
Analysis of single SNP and multiple SNPs was performed and relevance between plasmatic DBP and haplotypes was analyzed.
Results.
GC rs17467825 GG genotype was statistically associated with lower risk for generalized aggressive periodontitis under the recessive model (OR = 0.52, 95% CI: 0.30–0.92, p=0.028).
GC rs17467825 and rs4588 had strong linkage disequilibrium with r2≥0.8 and D′≥0.8.
Haplotype (GC rs17467825, rs4588) GC was associated with the less risk for generalized aggressive periodontitis (OR = 0.29, 95% CI: 0.09–0.96, p=0.043).
In group AgP, individuals with combined genotype (GC rs17467825, rs4588) AG+CA had significantly lower plasmatic DBP level than those with the other two combined genotypes (AG+CA versus AA+CC p=0.007; AG+CA versus GG+AA p=0.026).
Conclusions.
GC rs17467825 genotype GG and haplotype (GC rs17467825, rs4588) GC are associated with generalized aggressive periodontitis.
The association may be acquired through regulating DBP levels.
The functions of GC gene and DBP in inflammatory disease need to be further studied.
American Psychological Association (APA)
Song, Wenli& Wang, Xian’e& Tian, Yu& Zhang, Xin& Lu, Ruifang& Meng, Huanxin. 2016. GC Gene Polymorphisms and Vitamin D-Binding Protein Levels Are Related to the Risk of Generalized Aggressive Periodontitis. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1105906
Modern Language Association (MLA)
Song, Wenli…[et al.]. GC Gene Polymorphisms and Vitamin D-Binding Protein Levels Are Related to the Risk of Generalized Aggressive Periodontitis. International Journal of Endocrinology No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1105906
American Medical Association (AMA)
Song, Wenli& Wang, Xian’e& Tian, Yu& Zhang, Xin& Lu, Ruifang& Meng, Huanxin. GC Gene Polymorphisms and Vitamin D-Binding Protein Levels Are Related to the Risk of Generalized Aggressive Periodontitis. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1105906
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105906