Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate
Joint Authors
Bevilacqua, Arturo
Cucina, Alessandra
Dinicola, Simona
Bizzarri, Mariano
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-04
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Inositols (myo-inositol and inositol hexakisphosphate) exert a wide range of critical activities in both physiological and pathological settings.
Deregulated inositol metabolism has been recorded in a number of diseases, including cancer, where inositol modulates different critical pathways.
Inositols inhibit pRB phosphorylation, fostering the pRB/E2F complexes formation and blocking progression along the cell cycle.
Inositols reduce PI3K levels, thus counteracting the activation of the PKC/RAS/ERK pathway downstream of PI3K activation.
Upstream of that pathway, inositols disrupt the ligand interaction between FGF and its receptor as well as with the EGF-transduction processes involving IGF-II receptor and AP-1 complexes.
Additionally, Akt activation is severely impaired upon inositol addition.
Downregulation of both Akt and ERK leads consequently to NF-kB inhibition and reduced expression of inflammatory markers (COX-2 and PGE2).
Remarkably, inositol-induced downregulation of presenilin-1 interferes with the epithelial-mesenchymal transition and reduces Wnt-activation, β-catenin translocation, Notch-1, N-cadherin, and SNAI1 release.
Inositols interfere also with the cytoskeleton by upregulating Focal Adhesion Kinase and E-cadherin and decreasing Fascin and Cofilin, two main components of pseudopodia, leading hence to invasiveness impairment.
This effect is reinforced by the inositol-induced inhibition on metalloproteinases and ROCK1/2 release.
Overall, these effects enable inositols to remodel the cytoskeleton architecture.
American Psychological Association (APA)
Bizzarri, Mariano& Dinicola, Simona& Bevilacqua, Arturo& Cucina, Alessandra. 2016. Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1105928
Modern Language Association (MLA)
Bizzarri, Mariano…[et al.]. Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate. International Journal of Endocrinology No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1105928
American Medical Association (AMA)
Bizzarri, Mariano& Dinicola, Simona& Bevilacqua, Arturo& Cucina, Alessandra. Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1105928
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105928