Hospital Admission Patterns in Children with CAH: Admission Rates and Adrenal Crises Decline with Age

Abstract EN

Objective.

To examine patterns of hospitalisation for acute medical conditions in children with congenital adrenal hyperplasia (CAH).

Design.

A retrospective study of hospitalisation using administrative data.

Setting.

All hospitals in NSW, Australia.

Patients.

All patients admitted with CAH and a random sample of admissions in patients aged 0 to 18 years without adrenal insufficiency (AI).

Main Outcome Measures.

Admissions and comorbidities by age and sex.

Results.

Of 573 admissions for medical problems in CAH children, 286 (49.9%) were in males, and 236 (41.2%) had a principal diagnosis of CAH or had an adrenal crisis (AC).

37 (6.5%) ACs were recorded.

An infection was found in 43.5% (n=249) of the CAH patient admissions and 51.7% (n=1613) of the non-AI group, p<0.001.

Children aged up to one year had the highest number of admissions (n=149) and six ACs (four in males).

There were 21 ACs recorded for children aged 1–5 years.

Older CAH children had fewer admissions and fewer ACs.

No in-hospital deaths were recorded.

Conclusions.

Admission for medical problems in CAH children declines with age.

An AC was recorded in 6.5% of the admissions, with the majority of ACs occurring in the 1 to 5 years age group and there were no deaths.