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Pharmacogenetics of Risperidone and Cardiovascular Risk in Children and Adolescents
Joint Authors
Guerra-Júnior, Gil
Dos Santos-Júnior, Amilton
Henriques, Taciane Barbosa
Della Torre, Osmar Henrique
Paes, Lúcia Arisaka
Ferreira-Neto, Adriana Perez
Sewaybricker, Letícia Esposito
Fontana, Thiago Salum
Celeri, Eloisa Helena Rubello Valler
Dalgalarrondo, Paulo
de Mello, Maricilda Palandi
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
To identify the frequency of obesity and metabolic complications in child and adolescent users of risperidone.
Potential associations with clinical parameters and SNPs of the HTR2C, DRD2, LEP, LEPR, MC4R, and CYP2D6 genes were analyzed.
Methods.
Samples from 120 risperidone users (8–20 years old) were collected and SNPs were analyzed, alongside assessment of chronological and bone ages, prescribed and weight-adjusted doses, use of other psychotropic drugs, waist circumference, BMI z -scores, blood pressure, HOMA-IR index, fasting levels of serum glucose, insulin, cholesterol, triglycerides, transaminases, and leptin.
Results.
Thirty-two (26.7%) patients were overweight and 5 (4.2%) obese.
Hypertension was recorded in 8 patients (6.7%), metabolic syndrome in 6 (5%), and increased waist circumference in 20 (16.7%).
The HOMA-IR was high for 22 patients (18.3%), while total cholesterol and triglycerides were high in 20 (16.7%) and 41 (34.2%) patients, respectively.
SNP associations were found for LEP, HTR2C, and CYP2D6 with BMI; CYP2D6 with blood pressure, ALT, and HOMA-IR; HTR2C and LEPR with leptin levels; MC4R and DRD2 with HOMA-IR; HTR2C with WC; and LEP with ALT.
Conclusions.
Although not higher than in the general pediatric population, a high frequency of patients was overweight/obese, with abnormalities in metabolic parameters and some pharmacogenetic associations.
American Psychological Association (APA)
Dos Santos-Júnior, Amilton & Henriques, Taciane Barbosa& de Mello, Maricilda Palandi& Della Torre, Osmar Henrique& Paes, Lúcia Arisaka& Ferreira-Neto, Adriana Perez…[et al.]. 2016. Pharmacogenetics of Risperidone and Cardiovascular Risk in Children and Adolescents. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1105932
Modern Language Association (MLA)
Dos Santos-Júnior, Amilton…[et al.]. Pharmacogenetics of Risperidone and Cardiovascular Risk in Children and Adolescents. International Journal of Endocrinology No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1105932
American Medical Association (AMA)
Dos Santos-Júnior, Amilton & Henriques, Taciane Barbosa& de Mello, Maricilda Palandi& Della Torre, Osmar Henrique& Paes, Lúcia Arisaka& Ferreira-Neto, Adriana Perez…[et al.]. Pharmacogenetics of Risperidone and Cardiovascular Risk in Children and Adolescents. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1105932
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105932