Metabolism and Ovarian Function in PCOS Women: A Therapeutic Approach with Inositols
Joint Authors
Granese, Roberta
Rossetti, Paola
Buscema, Massimo
Gullo, Giuseppe
Triolo, Onofrio
Lagana, Antonio Simone
Condorelli, Rosita A.
La Vignera, Sandro
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Polycystic ovary syndrome (PCOS) is characterized by chronical anovulation and hyperandrogenism which may be present in a different degree of severity.
Insulin-resistance and hyperinsulinemia are the main physiopathological basis of this syndrome and the failure of inositol-mediated signaling may concur to them.
Myo (MI) and D-chiro-inositol (DCI), the most studied inositol isoforms, are classified as insulin sensitizers.
In form of glycans, DCI-phosphoglycan and MI-phosphoglycan control key enzymes were involved in glucose and lipid metabolism.
In form of phosphoinositides, they play an important role as second messengers in several cellular biological functions.
Considering the key role played by insulin-resistance and androgen excess in PCOS patients, the insulin-sensitizing effects of both MI and DCI were tested in order to ameliorate symptoms and signs of this syndrome, including the possibility to restore patients’ fertility.
Accumulating evidence suggests that both isoforms of inositol are effective in improving ovarian function and metabolism in patients with PCOS, although MI showed the most marked effect on the metabolic profile, whereas DCI reduced hyperandrogenism better.
The purpose of this review is to provide an update on inositol signaling and correlate data on biological functions of these multifaceted molecules, in view of a rational use for the therapy in women with PCOS.
American Psychological Association (APA)
Lagana, Antonio Simone& Rossetti, Paola& Buscema, Massimo& La Vignera, Sandro& Condorelli, Rosita A.& Gullo, Giuseppe…[et al.]. 2016. Metabolism and Ovarian Function in PCOS Women: A Therapeutic Approach with Inositols. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1105940
Modern Language Association (MLA)
Lagana, Antonio Simone…[et al.]. Metabolism and Ovarian Function in PCOS Women: A Therapeutic Approach with Inositols. International Journal of Endocrinology No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1105940
American Medical Association (AMA)
Lagana, Antonio Simone& Rossetti, Paola& Buscema, Massimo& La Vignera, Sandro& Condorelli, Rosita A.& Gullo, Giuseppe…[et al.]. Metabolism and Ovarian Function in PCOS Women: A Therapeutic Approach with Inositols. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1105940
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105940