Effects of Thyroid Peroxidase Antibody on Maternal and Neonatal Outcomes in Pregnant Women in an Iodine-Sufficient Area in China
Joint Authors
Huang, Xiaoping
Chen, Xi
Jin, Bai
Xia, Jun
Tao, Xincheng
Sun, Lu
Yuan, Qingxin
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purposes.
To evaluate the effects of thyroid peroxidase antibodies (TPOAb) on maternal and neonatal adverse outcomes in pregnant women.
Methods.
208 pregnant women at 24–28 weeks were divided into two groups, TPOAb-positive and TPOAb-negative groups.
Thyroid function and TPOAb were determined in all subjects until 12 months postpartum.
Levothyroxine was supplemented to maintain euthyroid with periodical checking of thyroid functions.
The prevalence of postpartum thyroiditis (PPT), placenta previa, placental abruption, premature rupture of membrane, postpartum haemorrhage, polyhydramnios, oligohydramnios, preterm birth, low birth weight, congenital hypothyroidism, and neonatal diseases were observed in two groups.
Results.
Of all women, 11.54% had a PPT.
The prevalence of PPT was significantly higher in TPOAb-positive than TPOAb-negative group (42.31% versus 7.14%, P < 0.001 ), with 45.46% and 53.85% of PPT happening at 6 weeks postpartum in TPOAb-positive and TPOAb-negative groups.
The incidence of polyhydramnios was significantly higher in TPOAb-positive than TPOAb-negative group (15.38% versus 2.74%, P = 0.02 ).
Conclusion.
Pregnant women with TPOAb-positive had increased risk of PPT, predominantly happening at 6 weeks postpartum.
TPOAb was associated with increased incidence of polyhydramnios and the underlying mechanisms required further investigation.
Earlier screening of thyroid function during pregnancy and postpartum was warranted in our region.
American Psychological Association (APA)
Chen, Xi& Jin, Bai& Xia, Jun& Tao, Xincheng& Huang, Xiaoping& Sun, Lu…[et al.]. 2016. Effects of Thyroid Peroxidase Antibody on Maternal and Neonatal Outcomes in Pregnant Women in an Iodine-Sufficient Area in China. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1105953
Modern Language Association (MLA)
Chen, Xi…[et al.]. Effects of Thyroid Peroxidase Antibody on Maternal and Neonatal Outcomes in Pregnant Women in an Iodine-Sufficient Area in China. International Journal of Endocrinology No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1105953
American Medical Association (AMA)
Chen, Xi& Jin, Bai& Xia, Jun& Tao, Xincheng& Huang, Xiaoping& Sun, Lu…[et al.]. Effects of Thyroid Peroxidase Antibody on Maternal and Neonatal Outcomes in Pregnant Women in an Iodine-Sufficient Area in China. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1105953
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105953