The Frequency of Langerhans Islets β-Cells Autoantibodies (Anti-GAD) in Georgian Children and Adolescents with Chronic Autoimmune Thyroiditis
Joint Authors
Giorgadze, Elene
Balakhadze, Mariam
Lomidze, Marina
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-27
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Aim.
Chronic autoimmune thyroiditis and type 1 diabetes mellitus are organ-specific autoimmune diseases.
There is large evidence that autoimmunity against the thyroid gland in patients with type 1 diabetes mellitus is increased, but little is known about anti-islet cell autoimmune status in patients with chronic autoimmune thyroiditis.
We evaluated the concentration of antibodies against glutamic acid decarboxylase (GAD) which are widely used as a diagnostic and predictive tool for type 1 diabetes mellitus, in school-aged Georgian children with chronic autoimmune thyroiditis.
Methods.
The frequency of anti-GAD antibodies was measured in Georgian school-aged children with chronic autoimmune thyroiditis and compared to healthy age and sex matched controls.
Results.
Of the 41 patients with chronic autoimmune thyroiditis 4 (9.8%) were positive for GAD antibodies.
The frequency of GAD positivity in the chronic autoimmune thyroiditis group was significantly higher than in the control subjects ( P = 0.036 ).
Conclusion.
In the study we found that the frequency of GAD antibody positivity in autoimmune thyroiditis patients was significantly higher (9.8%, P = 0.036 ) than in the control group.
Our findings support the concept that patients with autoimmune thyroid disease may develop type 1 diabetes mellitus in future life.
American Psychological Association (APA)
Balakhadze, Mariam& Giorgadze, Elene& Lomidze, Marina. 2016. The Frequency of Langerhans Islets β-Cells Autoantibodies (Anti-GAD) in Georgian Children and Adolescents with Chronic Autoimmune Thyroiditis. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1105954
Modern Language Association (MLA)
Balakhadze, Mariam…[et al.]. The Frequency of Langerhans Islets β-Cells Autoantibodies (Anti-GAD) in Georgian Children and Adolescents with Chronic Autoimmune Thyroiditis. International Journal of Endocrinology No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1105954
American Medical Association (AMA)
Balakhadze, Mariam& Giorgadze, Elene& Lomidze, Marina. The Frequency of Langerhans Islets β-Cells Autoantibodies (Anti-GAD) in Georgian Children and Adolescents with Chronic Autoimmune Thyroiditis. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1105954
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105954