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Circulating Visfatin in Hypothyroidism Is Associated with Free Thyroid Hormones and Antithyroperoxidase Antibodies
Joint Authors
Ruchała, Marek
Mańkowska-Wierzbicka, Dorota
Sawicka-Gutaj, Nadia
Zybek-Kocik, Ariadna
Klimowicz, Aleksandra
Kloska, Michał
Sowiński, Jerzy
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We hypothesized that regulation of visfatin in hypothyroidism might be altered by coexisting chronic autoimmune thyroiditis.
This is a prospective case-control study of 118 subjects.
The autoimmune study group (AIT) consisted of 39 patients newly diagnosed with hypothyroidism in a course of chronic autoimmune thyroiditis.
The nonautoimmune study group (TT) consisted of 40 patients thyroidectomized due to the differentiated thyroid cancer staged pT1.
The control group comprised 39 healthy volunteers adjusted for age, sex, and BMI with normal thyroid function and negative thyroid antibodies.
Exclusion criteria consisted of other autoimmune diseases, active neoplastic disease, diabetes mellitus, and infection, which were reported to alter visfatin level.
Fasting blood samples were taken for visfatin, TSH, free thyroxine (FT4), free triiodothyronine (FT3), antithyroperoxidase antibodies (TPOAb), antithyroglobulin antibodies (TgAb), glucose, and insulin levels.
The highest visfatin serum concentration was in AIT group, and healthy controls had visfatin level higher than TT (p=0.0001).
Simple linear regression analysis revealed that visfatin serum concentration was significantly associated with autoimmunity (β=0.1014; p=0.003), FT4 (β=0.05412; p=0.048), FT3 (β=0.05242; p=0.038), and TPOAb (β=0.0002; p=0.0025), and the relationships were further confirmed in the multivariate regression analysis.
American Psychological Association (APA)
Sawicka-Gutaj, Nadia& Zybek-Kocik, Ariadna& Klimowicz, Aleksandra& Kloska, Michał& Mańkowska-Wierzbicka, Dorota& Sowiński, Jerzy…[et al.]. 2016. Circulating Visfatin in Hypothyroidism Is Associated with Free Thyroid Hormones and Antithyroperoxidase Antibodies. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1105975
Modern Language Association (MLA)
Sawicka-Gutaj, Nadia…[et al.]. Circulating Visfatin in Hypothyroidism Is Associated with Free Thyroid Hormones and Antithyroperoxidase Antibodies. International Journal of Endocrinology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1105975
American Medical Association (AMA)
Sawicka-Gutaj, Nadia& Zybek-Kocik, Ariadna& Klimowicz, Aleksandra& Kloska, Michał& Mańkowska-Wierzbicka, Dorota& Sowiński, Jerzy…[et al.]. Circulating Visfatin in Hypothyroidism Is Associated with Free Thyroid Hormones and Antithyroperoxidase Antibodies. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1105975
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105975