Long-Term Quality of Life and Pregnancy Outcomes of Differentiated Thyroid Cancer Survivors Treated by Total Thyroidectomy and I131 during Adolescence and Young Adulthood
Joint Authors
Brunaud, L.
Metallo, Melanie
Groza, Lelia
Klein, Marc
Weryha, Georges
Feigerlova, Eva
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
Differentiated thyroid cancer (DTC) is rare and confers good prognosis.
Long-term health related quality of life (HRQoL) and pregnancy outcomes are not well known in subjects treated during adolescence and young adulthood.
Methods.
Cross-sectional analysis of HRQoL and global self-esteem, using SF-36 and ISP-25 surveys, and of pregnancy outcomes in female survivors of DTC treated by total thyroidectomy and I131 before age of 25 years.
Results.
Forty-five of 61 patients (74%) responded to the survey.
Cumulative I131 activity was ≤3.85 GBq in 18 subjects and >3.85 GBq in 27 subjects.
Mean time from diagnosis was 7.6 ± 5.2 years for the group ≤ 3.85 GBq versus 16.9 ± 11.6 years for the group > 3.85 GBq (P<0.05).
No significant alteration in long-term HRQoL and global self-esteem was observed.
Thirty pregnancies after I131 were noted in patients from the group > 3.85 GBq and 10 in patients from the group ≤ 3.85 GBq.
Frequency of miscarriages was of 17% (group > 3.85 GBq) and 10% (group ≤ 3.85 GBq) with 9 and 24 live births, respectively.
No congenital malformations or first year mortality was noted.
Conclusion.
Long-term HRQoL, global self-esteem, and pregnancy outcomes are not affected in young female survivors of DTC.
American Psychological Association (APA)
Metallo, Melanie& Groza, Lelia& Brunaud, L.& Klein, Marc& Weryha, Georges& Feigerlova, Eva. 2016. Long-Term Quality of Life and Pregnancy Outcomes of Differentiated Thyroid Cancer Survivors Treated by Total Thyroidectomy and I131 during Adolescence and Young Adulthood. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1105977
Modern Language Association (MLA)
Metallo, Melanie…[et al.]. Long-Term Quality of Life and Pregnancy Outcomes of Differentiated Thyroid Cancer Survivors Treated by Total Thyroidectomy and I131 during Adolescence and Young Adulthood. International Journal of Endocrinology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1105977
American Medical Association (AMA)
Metallo, Melanie& Groza, Lelia& Brunaud, L.& Klein, Marc& Weryha, Georges& Feigerlova, Eva. Long-Term Quality of Life and Pregnancy Outcomes of Differentiated Thyroid Cancer Survivors Treated by Total Thyroidectomy and I131 during Adolescence and Young Adulthood. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1105977
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105977