Chronic Glucocorticoid-Rich Milieu and Liver Dysfunction
Joint Authors
Schinella, Guillermo
Villagarcía, Hernán Gonzalo
Sabugo, Vanesa
Castro, María Cecilia
Castrogiovanni, Daniel
Massa, María Laura
Francini, Flavio
Spinedi, Eduardo
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
We investigated the impact of chronic hypercorticosteronemia (due to neonatal monosodium L-glutamate, MSG, and treatment) on liver oxidative stress (OS), inflammation, and carbohydrate/lipid metabolism in adult male rats.
We evaluated the peripheral concentrations of several metabolic and OS markers and insulin resistance indexes.
In liver we assessed (a) OS (GSH and protein carbonyl groups) and inflammatory (IL-1b, TNFa, and PAI-1) biomarkers and (b) carbohydrate and lipid metabolisms.
MSG rats displayed degenerated optic nerves, hypophagia, low body and liver weights, and enlarged adipose tissue mass; higher peripheral levels of glucose, triglycerides, insulin, uric acid, leptin, corticosterone, transaminases and TBARS, and peripheral and liver insulin resistance; elevated liver OS, inflammation markers, and glucokinase (mRNA/activity) and fructokinase (mRNA).
Additionally, MSG liver phosphofructokinase-2, glucose-6-phosphatase (mRNA and activity) and glucose-6-phosphate dehydrogenase, Chrebp, Srebp1c, fatty acid synthase, and glycerol-3-phosphate (mRNAs) were increased.
In conclusion adult MSG rats developed an insulin-resistant state and increased OS and serious hepatic dysfunction characterized by inflammation and metabolic signs suggesting increased lipogenesis.
These features, shared by both metabolic and Cushing’s syndrome human phenotypes, support that a chronic glucocorticoid-rich endogenous environment mainly impacts on hepatic glucose cycle, displacing local metabolism to lipogenesis.
Whether correcting the glucocorticoid-rich environment ameliorates such dysfunctions requires further investigation.
American Psychological Association (APA)
Villagarcía, Hernán Gonzalo& Sabugo, Vanesa& Castro, María Cecilia& Schinella, Guillermo& Castrogiovanni, Daniel& Spinedi, Eduardo…[et al.]. 2016. Chronic Glucocorticoid-Rich Milieu and Liver Dysfunction. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1105997
Modern Language Association (MLA)
Villagarcía, Hernán Gonzalo…[et al.]. Chronic Glucocorticoid-Rich Milieu and Liver Dysfunction. International Journal of Endocrinology No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1105997
American Medical Association (AMA)
Villagarcía, Hernán Gonzalo& Sabugo, Vanesa& Castro, María Cecilia& Schinella, Guillermo& Castrogiovanni, Daniel& Spinedi, Eduardo…[et al.]. Chronic Glucocorticoid-Rich Milieu and Liver Dysfunction. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1105997
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105997