Predictive Factors of Development of Graves’ Ophthalmopathy for Patients with Juvenile Graves’ Disease
Joint Authors
Jarusaitiene, Dalia
Verkauskiene, Rasa
Jasinskas, Vytautas
Jankauskiene, J.
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Due to low incidence of Graves’ ophthalmopathy (GO) among children, the manifestation is poorly analyzed, posing a risk to late identification of insidious disease.
Purposes.
To identify predictive factors that may influence the development of GO in pediatric and young patients with Graves’ disease (GD).
Methods.
A cross-sectional study of patients newly diagnosed with pediatric or juvenile GD during 2002–2012 was conducted at the Hospital of Lithuanian University of Health Sciences.
Ocular evaluation was based on European Group on Graves’ Orbitopathy survey.
The ocular manifestations were analyzed in relation to demographic, environmental, and clinical factors.
Results.
In total, 130 patients with juvenile GD were included; 29.2% had GO.
Median age at GD onset was 17 yrs (IQR 4–29).
Main symptoms of GO were eyelids retraction (73.7%), proptosis (65.8%), injection of conjunctiva (42.1%), and eyeball motility disturbance (21.1%).
Major significant and independent risk factors for GO development were high initial concentration of FT4 (OR = 5.963), TTHAb (OR = 6.358), stress (OR = 6.030), and smoking (OR = 7.098).
Conclusion.
The major factors that could influence GO development were smoking, stress, and increased levels of initial TRAb, FT4.
Slight proptosis, retraction of eyelids, and conjunctive injection were found as predominant ophthalmological symptoms in juvenile GO.
American Psychological Association (APA)
Jarusaitiene, Dalia& Verkauskiene, Rasa& Jasinskas, Vytautas& Jankauskiene, J.. 2016. Predictive Factors of Development of Graves’ Ophthalmopathy for Patients with Juvenile Graves’ Disease. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1106002
Modern Language Association (MLA)
Jarusaitiene, Dalia…[et al.]. Predictive Factors of Development of Graves’ Ophthalmopathy for Patients with Juvenile Graves’ Disease. International Journal of Endocrinology No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1106002
American Medical Association (AMA)
Jarusaitiene, Dalia& Verkauskiene, Rasa& Jasinskas, Vytautas& Jankauskiene, J.. Predictive Factors of Development of Graves’ Ophthalmopathy for Patients with Juvenile Graves’ Disease. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1106002
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106002