Relationship between Branched-Chain Amino Acids, Metabolic Syndrome, and Cardiovascular Risk Profile in a Chinese Population: A Cross-Sectional Study
Joint Authors
Yang, Tao
Hu, Wen
Sun, Luning
Gong, Yingyun
Zhou, Ying
Yang, Panpan
Ye, Zhengqin
Fu, Jinxiang
Huang, Aijie
Fu, Zhenzhen
Yu, Weinan
Zhao, Yang
Zhou, Hongwen
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
This study aimed to evaluate the relationship between branched-chain amino acids (BCAAs), metabolic syndrome (MS), and other cardiovascular (CV) risk factors in middle-aged and elderly Chinese population at high risk for the development of cardiovascular disease (CVD).
Methods.
1302 subjects were enrolled from the Huai’an Diabetes Prevention Program.
Results.
BCAAs levels were positively correlated with MS, its components, and CV risk profile.
The odds ratio (OR) for MS among subjects in the fourth quartile of BCAAs levels showed a 2.17-fold increase compared with those in the first quartile.
BCAAs were independently associated with high Framingham risk score even after adjusting for MS and its components ( P < 0.0001 ).
Additionally, the OR for high CV risk was 3.20-fold ( P < 0.0001 ) in participants in the fourth BCAAs quartile with MS compared with participants in the first BCAAs quartile without MS.
Conclusions.
Increased BCAAs levels are independent risk factors of MS and CVD in addition to the traditional factors in middle-aged and elderly Chinese population.
The development of CVD in MS patients with high level BCAAs is accelerated.
Intervention studies are needed to investigate whether the strategy of BCAAs reduction has impacts on endpoints in patients with higher CV risk.
This study is registered with ChiCTR-TRC-14005029.
American Psychological Association (APA)
Hu, Wen& Sun, Luning& Gong, Yingyun& Zhou, Ying& Yang, Panpan& Ye, Zhengqin…[et al.]. 2016. Relationship between Branched-Chain Amino Acids, Metabolic Syndrome, and Cardiovascular Risk Profile in a Chinese Population: A Cross-Sectional Study. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1106004
Modern Language Association (MLA)
Hu, Wen…[et al.]. Relationship between Branched-Chain Amino Acids, Metabolic Syndrome, and Cardiovascular Risk Profile in a Chinese Population: A Cross-Sectional Study. International Journal of Endocrinology No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1106004
American Medical Association (AMA)
Hu, Wen& Sun, Luning& Gong, Yingyun& Zhou, Ying& Yang, Panpan& Ye, Zhengqin…[et al.]. Relationship between Branched-Chain Amino Acids, Metabolic Syndrome, and Cardiovascular Risk Profile in a Chinese Population: A Cross-Sectional Study. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1106004
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106004