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Thyroid Hormones, Autoantibodies, Ultrasonography, and Clinical Parameters for Predicting Thyroid Cancer
Joint Authors
He, Lin-zheng
Zeng, Tian-shu
Pu, Lin
Pan, Shi-xiu
Xia, Wen-fang
Chen, Lu-lu
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Our objective was to evaluate thyroid nodule malignancy prediction using thyroid function tests, autoantibodies, ultrasonographic imaging, and clinical data.
We conducted a retrospective cohort study in 1400 patients with nodular thyroid disease (NTD).
The thyroid stimulating hormone (TSH) concentration was significantly higher in patients with differentiated thyroid cancer (DTC) versus benign thyroid nodular disease (BTND) ( p = 0.004 ).
The receiver operating characteristic curve of TSH showed an AUC of 0.58 (95% CI 0.53–0.62, p = 0.001 ), sensitivity of 74%, and specificity of 57% at a cut-off of 1.59 mIU/L.
There was an incremental increase in TSH concentration along with the increasing tumor size ( p < 0.001 ).
Thyroglobulin antibody (TgAb) concentration was associated with an increased risk of malignancy ( p = 0.029 ), but this association was lost when the effect of TSH was taken into account ( p = 0.11 ).
Thyroid ultrasonographic characteristics, including fewer than three nodules, hypoechoic appearance, solid component, poorly defined margin, intranodular or peripheral-intranodular flow, and punctate calcification, can be used to predict the risk of thyroid cancer.
In conclusion, our study suggests that preoperative serum TSH concentration, age, and ultrasonographic features can be used to predict the risk of malignancy in patients with NTD.
American Psychological Association (APA)
He, Lin-zheng& Zeng, Tian-shu& Pu, Lin& Pan, Shi-xiu& Xia, Wen-fang& Chen, Lu-lu. 2016. Thyroid Hormones, Autoantibodies, Ultrasonography, and Clinical Parameters for Predicting Thyroid Cancer. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1106006
Modern Language Association (MLA)
He, Lin-zheng…[et al.]. Thyroid Hormones, Autoantibodies, Ultrasonography, and Clinical Parameters for Predicting Thyroid Cancer. International Journal of Endocrinology No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1106006
American Medical Association (AMA)
He, Lin-zheng& Zeng, Tian-shu& Pu, Lin& Pan, Shi-xiu& Xia, Wen-fang& Chen, Lu-lu. Thyroid Hormones, Autoantibodies, Ultrasonography, and Clinical Parameters for Predicting Thyroid Cancer. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1106006
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106006