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Investigation of Vitamin D-Binding Protein Polymorphism Impact on Coronary Artery Disease and Relationship with Longevity: Own Data and a Review
Joint Authors
Benetis, Rimantas
Lesauskaitė, Vita
Girdauskaitė, Milda
Janulionis, Ernestas
Ulys, Albertas
Stakišaitis, Donatas
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The aim of the study was to assess the effect of vitamin D-binding protein (DBP) polymorphism on coronary artery disease (CAD).
DBP phenotypes were identified in the groups: control (n=306), men suffering from CAD (n=154), and long-lived individuals (n=108).
Isoelectric focusing of DBP phenotypes in serum was performed on polyacrylamide gel.
Distribution of DBP phenotypes in the study groups was found to be in Hardy-Weinberg equilibrium.
Gc1s-1s phenotype and Gc1s allele frequency in CAD groups were significantly higher than in control, and Gc1s allele frequency was found significantly more often in CAD compared with long-lived group (p<0.05).
The Gc2 allele frequency in control was higher as compared with Gc2 frequency in CAD group (p<0.05).
The Gc2-2 phenotype was more frequent in long-lived survivors than in the CAD group (p<0.05).
It was found that the Gc1s allele significantly increased the risk of CAD with the odds ratio (OR) equal to 1.45 (p<0.02) and showed Gc2 to be related with a decreased risk of CAD (OR = 0.69; p<0.03).
Authors review the role of DBP in resistance to atherosclerosis and cancer as the main longevity determinants.
American Psychological Association (APA)
Stakišaitis, Donatas& Lesauskaitė, Vita& Girdauskaitė, Milda& Janulionis, Ernestas& Ulys, Albertas& Benetis, Rimantas. 2016. Investigation of Vitamin D-Binding Protein Polymorphism Impact on Coronary Artery Disease and Relationship with Longevity: Own Data and a Review. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1106007
Modern Language Association (MLA)
Stakišaitis, Donatas…[et al.]. Investigation of Vitamin D-Binding Protein Polymorphism Impact on Coronary Artery Disease and Relationship with Longevity: Own Data and a Review. International Journal of Endocrinology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1106007
American Medical Association (AMA)
Stakišaitis, Donatas& Lesauskaitė, Vita& Girdauskaitė, Milda& Janulionis, Ernestas& Ulys, Albertas& Benetis, Rimantas. Investigation of Vitamin D-Binding Protein Polymorphism Impact on Coronary Artery Disease and Relationship with Longevity: Own Data and a Review. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1106007
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106007