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Long-Term Clinical Outcomes of Invasive Giant Prolactinomas after a Mean Ten-Year Followup
Joint Authors
Wu, Zhe Bao
Cai, Lin
Lin, Shao Jian
Wu, Ze Rui
Zhang, Yong
Su, Zhi Peng
Wei, Yong Xu
Shang, Han Bing
Yang, Wen Lei
Zhao, Wei Guo
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
The aim of this study is to observe clinical outcomes after more than ten years of followup in a group of patients with invasive giant prolactinomas (IGPs) treated with dopamine agonists (DAs).
Methods.
Twenty-five patients met the criteria of IGPs, among which 16 patients primarily received bromocriptine (BRC) and the other nine had undergone unsuccessful microsurgery prior to BRC treatment.
Results.
After a mean follow-up period of 135.5±4.7 months, the clinical symptoms in all patients improved by different degrees.
Tumor volume was decreased by a mean of 98.6%, and the tumors of 19 patients had almost completely disappeared.
The mean duration of treatment at maximal doses of BRC was 48.5 months.
At the last follow-up visit, nineteen patients had normal PRL levels, and 14 of these patients had received the low-dose BRC treatment (at an average of 2.9±0.3 mg/d).
Younger patients < 25 years had a significantly higher rate of persistent hyperprolactinemia after long-term BRC treatment (p=0.043).
Conclusion.
DAs are a first-line therapy for IGPs because they can effectively achieve long-term control in both shrinking tumor volume and normalizing the PRL level, and majority of patients need low-dose DA maintenance.
Younger patients are prone to persistent hyperprolactinemia despite long-term DA treatment.
American Psychological Association (APA)
Wu, Ze Rui& Zhang, Yong& Cai, Lin& Lin, Shao Jian& Su, Zhi Peng& Wei, Yong Xu…[et al.]. 2016. Long-Term Clinical Outcomes of Invasive Giant Prolactinomas after a Mean Ten-Year Followup. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1106029
Modern Language Association (MLA)
Wu, Ze Rui…[et al.]. Long-Term Clinical Outcomes of Invasive Giant Prolactinomas after a Mean Ten-Year Followup. International Journal of Endocrinology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1106029
American Medical Association (AMA)
Wu, Ze Rui& Zhang, Yong& Cai, Lin& Lin, Shao Jian& Su, Zhi Peng& Wei, Yong Xu…[et al.]. Long-Term Clinical Outcomes of Invasive Giant Prolactinomas after a Mean Ten-Year Followup. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1106029
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106029