Expression of miRNA and Occurrence of Distant Metastases in Patients with Hürthle Cell Carcinoma
Joint Authors
Besic, Nikola
Petric, Rok
Gazic, Barbara
Dzodic, Radan
Goričar, Katja
Dolžan, Vita
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Hürthle cell thyroid carcinoma (HCTC) is a rare type of thyroid carcinoma.
In the present study, we investigated whether the expression of miRNAs of interest is associated with the occurrence of metastases in patients with HCTC.
Materials and Methods.
In 39 patients with HCTC (22 with nonmetastatic and 17 with regional or distant metastatic disease), the expression levels of six miRNAs (miR-138, miR-183, miR-221, miR-222, miR-768-3p, and miR-885-5p) and U6 snRNA as endogenous control were determined in FFPE samples of primary tumor and normal thyroid tissue using TaqMan miRNA assays.
Results.
In patients with HCTC, miR-138 and miR-768-3p were downregulated in tumor samples compared to normal tissue ( p = 0.013 and p = 0.010 , resp.).
These two miRNAs were also significantly downregulated in tumor samples of patients with metastatic disease ( p = 0.030 and p = 0.048 , resp.) but not in patients with nonmetastatic disease ( p = 0.249 and p = 0.101 , resp.).
In patients with nonmetastatic disease, miR-221 and miR-885-5p were slightly, albeit significantly, upregulated in tumorous compared to normal tissue ( p = 0.042 and p = 0.027 , resp.).
Conclusion.
Expression of miRNA (miR-183, miR-221, and miR-885-5p) in tumor tissue is associated with the occurrence of distant metastases in patients with HCTC.
American Psychological Association (APA)
Petric, Rok& Gazic, Barbara& Goričar, Katja& Dolžan, Vita& Dzodic, Radan& Besic, Nikola. 2016. Expression of miRNA and Occurrence of Distant Metastases in Patients with Hürthle Cell Carcinoma. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1106041
Modern Language Association (MLA)
Petric, Rok…[et al.]. Expression of miRNA and Occurrence of Distant Metastases in Patients with Hürthle Cell Carcinoma. International Journal of Endocrinology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1106041
American Medical Association (AMA)
Petric, Rok& Gazic, Barbara& Goričar, Katja& Dolžan, Vita& Dzodic, Radan& Besic, Nikola. Expression of miRNA and Occurrence of Distant Metastases in Patients with Hürthle Cell Carcinoma. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1106041
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106041